The T1‐tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14279
Abstract: Cytoplasmic domains frequently promote functional assembly of multimeric ion channels. To investigate structural determinants of this process, we generated the ‘T1‐chimera’ construct of the NaChBac sodium channel by truncating its C‐terminal domain and splicing the… read more here.
Keywords: nachbac sodium; sodium channel; domain; channel ... See more keywords
Double sodium channel mutation, I265T/L1014F, is possibly related to pyrethroid-resistant in Thrips palmi.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.22021
Abstract: Thrips palmi Karny (Thysanoptera: Thripidae) can harm a variety of agricultural crops and transmit plant viruses, causing heavy economic losses. In the Hainan province of China, pyrethroids were sprayed widely to control T. palmi, which… read more here.
Keywords: palmi; thrips palmi; sodium channel; mutation i265t ... See more keywords
Synthetic Strategies and SAR Studies of Triazine‐Based Antiepileptic Agents: A Bench to Bedside Approach
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202500087
Abstract: Due to their strong biological activity, heterocyclic compounds containing triazine scaffolds are now of interest to a large number of organic chemists. It has been discovered that the triazine ring possesses antiepileptic properties. The article's… read more here.
Keywords: sar studies; studies triazine; triazine based; sodium channel ... See more keywords
Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000692
Abstract: Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5‐tetramethylpyrroline moiety, known for its antioxidant effect, in order… read more here.
Keywords: sodium channel; pyrroline derivatives; synthesis evaluation; evaluation voltage ... See more keywords
Phytol Enhances Anticonvulsant Effect of Carbamazepine and Diazepam Against PTZ‐Induced Convulsion in Chicks, Possibly Through Voltage‐Gated Sodium Channel and GABAA Interaction Pathways
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70162
Abstract: The chlorophyll‐derived diterpenoid phytol (PHY) is evident for its diverse biological effects, including neuroprotective activities in experimental animals. This study aims at the evaluation of anticonvulsant effects along with the possible mechanism of action of… read more here.
Keywords: effect; phy; gabaa; sodium channel ... See more keywords
Risk of sudden unexpected death in epilepsy (SUDEP) with lamotrigine and other sodium channel‐modulating antiseizure medications
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12693
Abstract: In vitro data prompted U.S Food and Drug Administration warnings that lamotrigine, a common sodium channel modulating anti‐seizure medication (NaM‐ASM), could increase the risk of sudden death in patients with structural or ischaemic cardiac disease,… read more here.
Keywords: channel modulating; risk sudden; sodium channel; death ... See more keywords
A Preliminary Toxicology Study on Eco-friendly Control Target of Spodoptera frugiperda
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Environmental Contamination and Toxicology"
DOI: 10.1007/s00128-020-03044-z
Abstract: Pyrethroid and indoxacarb are commonly used pesticides to control the fall armyworm ( Spodoptera frugiperda) in the crops. There are a series of consequences caused by the use of pyrethroid and indoxacarb pesticides under emergency… read more here.
Keywords: spodoptera frugiperda; sodium channel; frugiperda; toxicology ... See more keywords
Prostaglandin E2 Upregulated Trigeminal Ganglionic Sodium Channel 1.7 Involving Temporomandibular Joint Inflammatory Pain in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0552-2
Abstract: Prostaglandin E2 (PGE2) is a key proinflammatory mediator that contributes to inflammatory hyperalgesia. Voltage-gated sodium channel 1.7 (Nav1.7) plays an important role in inflammatory pain. However, the modulation of Nav1.7 in inflammatory pain remains poorly… read more here.
Keywords: inflammatory pain; temporomandibular joint; sodium channel; inflammatory ... See more keywords
Augmentation of pyrethrins content in callus of Chrysanthemum cinerariaefolium and establishing its insecticidal activity by molecular docking of NavMS Sodium Channel Pore receptor
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1387-8
Abstract: Pyrethrins are effective food-grade bio-pesticides obtained from the flowers of Chrysanthemum cinerariaefolium and this crop cannot be cultivated widely in India due to its specific agro-climatic requirement. Hence pyrethrins are mostly imported from Kenya. Therefore,… read more here.
Keywords: navms sodium; sodium channel; cinerariaefolium; chrysanthemum cinerariaefolium ... See more keywords
Positive Modulation of Human Nav Channels by Pyrethroids
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1315
Abstract: Voltage-gated sodium channels (Nav) are crucial to the initiation and propagation of action potentials in electrically excitable cells. Inhibitors of such ion channels have been developed and approved as drugs to treat a variety of… read more here.
Keywords: modulation human; positive modulation; human nav; sodium channel ... See more keywords
Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109483
Abstract: Loss-of-function variants in the gene SCN2A, which encodes the sodium channel NaV1.2, are strongly associated with autism spectrum disorder and intellectual disability. An estimated 20%-30% of children with these variants also suffer from epilepsy, with… read more here.
Keywords: channel loss; sodium channel; pyramidal cells; loss ... See more keywords