Voltage‐gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13641
Abstract: The voltage‐gated sodium channels (VGSCs) are aberrantly expressed in a variety of tumors and play an important role in tumor growth and metastasis. Here, we show that VGSCs auxiliary β3 subunit, encoded by the SCN3B… read more here.
Keywords: degradation; p53 degradation; p53; gated sodium ... See more keywords
Discovery of quinoline-derived trifluoromethyl alcohols as antiepileptic and analgesic agents that block sodium channels.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100547
Abstract: The discovery of novel analgesic agents with high potency, low toxicity and low addictive properties remain a priority. This study aims to identify the analgesic potential of quinoline derived α-trifluoromethylated alcohols (QTA) and their mechanism… read more here.
Keywords: quinoline derived; analgesic agents; sodium; antiepileptic analgesic ... See more keywords
Structural Models of Ligand-Bound Sodium Channels.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_44
Abstract: X-ray and cryo-EM structures of tetrameric and pseudo-tetrameric P-loop channels are used to elaborate homology models of mammalian voltage-gated sodium channels with drugs and neurotoxins. Such models integrate experimental data, assist in planning new experiments,… read more here.
Keywords: models ligand; structural models; sodium; bound sodium ... See more keywords
Toxins That Affect Voltage-Gated Sodium Channels.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_66
Abstract: Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years… read more here.
Keywords: pharmacology; gated sodium; sodium channels; voltage gated ... See more keywords
[Pain and analgesia : Mutations of voltage-gated sodium channels].
Sign Up to like & getrecommendations! Published in 2017 at "Schmerz"
DOI: 10.1007/s00482-016-0139-0
Abstract: Voltage-gated sodium channels (Navs) are crucial for the generation and propagation of action potentials in all excitable cells, and therefore for the function of sensory neurons as well. Preclinical research over the past 20 years identified… read more here.
Keywords: function; gated sodium; sodium channels; pain ... See more keywords
State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0429-0
Abstract: SummaryBackground and Purpose IC261 (3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one) has previously been introduced as an isoform specific inhibitor of casein kinase 1 (CK1) causing cell cycle arrest or cell death of established tumor cell lines. However, it is reasonable… read more here.
Keywords: state; ic261; sodium; gated sodium ... See more keywords
Expression and purification of recombinant alpha-toxin AnCra1 from the scorpion Androctonus crassicauda and its functional characterization on mammalian sodium channels.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06624-2
Abstract: BACKGROUND Alpha-scorpion toxins with long-chain peptide and four disulfide bonds represent diverse pharmacological profiles for various subtypes of voltage-gated sodium channels. Obtaining the natural toxins are difficult and time-consuming process, which represents the major difficulty… read more here.
Keywords: toxin ancra1; scorpion androctonus; scorpion; toxin ... See more keywords
How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology Reports"
DOI: 10.1007/s11033-021-06642-0
Abstract: Severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) is the causative agent of current coronavirus disease 2019 (COVID-19) pandemic. Electrolyte disorders particularly potassium abnormalities have been repeatedly reported as common clinical manifestations of COVID-19. Here, we… read more here.
Keywords: potassium; affect potassium; potassium balance; epithelial sodium ... See more keywords
Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?
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DOI: 10.1007/s11596-019-2117-0
Abstract: Voltage-gated sodium (Nav) channels are critical players in the generation and propagation of action potentials by triggering membrane depolarization. Mutations in Nav channels are associated with a variety of channelopathies, which makes them relevant targets… read more here.
Keywords: channels blockers; nav channels; gated sodium; sodium channels ... See more keywords
Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-017-0132-3
Abstract: Abstract Voltage-gated sodium channels (Navs) play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human… read more here.
Keywords: expression role; expression; role; gated sodium ... See more keywords
[Lidocaine in oncological surgery: the role of blocking in voltage-gated sodium channels. A narrative review].
Sign Up to like & getrecommendations! Published in 2020 at "Revista brasileira de anestesiologia"
DOI: 10.1016/j.bjan.2020.04.018
Abstract: BACKGROUND The current evidence suggests that oncological surgery, which is a therapy used in the treatment of solid tumors, increases the risk of metastasis. In this regard, a wide range of tumor cells express Voltage-Gated… read more here.
Keywords: tumor cells; oncological surgery; gated sodium; sodium channels ... See more keywords