Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy
Sign Up to like & getrecommendations! Published in 2017 at "Current Heart Failure Reports"
DOI: 10.1007/s11897-017-0333-0
Abstract: Purpose of reviewOver the last years, evidence is accumulating that enhanced late sodium current (INaL) in cardiac pathologies has fundamental consequences for cellular electrophysiology. This review discusses the underlying mechanisms of INaL-induced arrhythmias and the… read more here.
Keywords: late sodium; sodium current; heart failure; current innovative ... See more keywords
Isoliensinine Eliminates Afterdepolarizations Through Inhibiting Late Sodium Current and L-Type Calcium Current
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09597-z
Abstract: Isoliensinine (IL) extracted from lotus seed has a good therapeutic effect on cardiovascular diseases. However, its effect on ion channels of ventricular myocytes is still unclear. We used whole-cell patch-clamp techniques to detect the effects… read more here.
Keywords: late sodium; sodium current; calcium current; type calcium ... See more keywords
A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.06.047
Abstract: Neuronal subthreshold voltage-dependent currents determine membrane properties such as the input resistance (Rin) and the membrane time constant (τm) in the subthreshold range. In contrast with classical cable theory predictions, the persistent sodium current (INaP),… read more here.
Keywords: sodium current; conductance; negative slope; slope conductance ... See more keywords
Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.025
Abstract: SUMMARY Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,… read more here.
Keywords: cardiac myocytes; late sodium; sumoylation nav1; sodium current ... See more keywords
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172444
Abstract: Studies demonstrated that the incidence of atrial fibrillation is significantly increased in patients with diabetes mellitus. Increase of late sodium current (INaL) has been associated with atrial arrhythmias. However, the role of INaL in the… read more here.
Keywords: atrial fibrillation; late sodium; sodium current; diabetic mice ... See more keywords
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01056-0
Abstract: Cardiac arrhythmias associated with intracellular calcium inhomeostasis are refractory to antiarrhythmic therapy. We hypothesized that late sodium current (INa) contributed to the calcium-related arrhythmias. Monophasic action potential duration at 90% completion of repolarization (MAPD90) was… read more here.
Keywords: late sodium; sodium current; ventricular arrhythmias; calcium ... See more keywords
Late sodium current and calcium homeostasis in arrhythmogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1854986
Abstract: ABSTRACT The cardiac late sodium current (INa,late) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of the current can lead… read more here.
Keywords: ina late; homeostasis; late sodium; sodium current ... See more keywords
Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide
Sign Up to like & getrecommendations! Published in 2022 at "Europace"
DOI: 10.1093/europace/euac218
Abstract: Abstract Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in genes encoding ion channels are associated with familial AF. The point mutation M1875T in the SCN5A gene, which encodes the α-subunit… read more here.
Keywords: mutation; sodium current; sodium; scn5a m1875t ... See more keywords
Late sodium current in atrial cardiomyocytes contributes to the induced and spontaneous atrial fibrillation in rabbit hearts.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000883
Abstract: Increased late sodium current (INa) induces long QT syndrome 3 with increased risk of atrial fibrillation (AF). The role of atrial late INa in the induction of AF and in the treatment of AF was… read more here.
Keywords: ina; rabbit hearts; late sodium; atrial fibrillation ... See more keywords
The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17149
Abstract: This study investigates the effects of PRAX‐562 on sodium current (INa), intrinsic neuronal excitability, and protection from evoked seizures to determine whether a preferential persistent INa inhibitor would exhibit improved preclinical efficacy and tolerability compared… read more here.
Keywords: sodium; inhibitor; sodium channel; prax 562 ... See more keywords
Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12798
Abstract: Melatonin treatment was reported to reduce the risk of cardiac arrhythmias, and crucial for this antiarrhythmic action was the effect of melatonin on activation spread. The aim of the present study was evaluation of the… read more here.
Keywords: activation; conduction; sodium current; melatonin treatment ... See more keywords