(–)-Epicatechin Provides Neuroprotection in Sodium Iodate-Induced Retinal Degeneration
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DOI: 10.3389/fmed.2022.879901
Abstract: Oxidative stress, mitochondrial impairment, and pathological amyloid beta (Aβ) deposition are involved in the pathogenesis of dry age-related macular degeneration (AMD). The natural flavonoid (–)-epicatechin (EC) is known to be an antioxidant and neuroprotective compound.… read more here.
Keywords: sodium iodate; epicatechin provides; degeneration; retinal degeneration ... See more keywords
Glabridin Attenuates the Retinal Degeneration Induced by Sodium Iodate In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.566699
Abstract: Background Age-related macular degeneration (AMD) is one of the major causes of blindness in the elderly over the age of 60. AMD is divided into dry AMD and wet AMD. Although there are certain treatment… read more here.
Keywords: glab; vitro vivo; retinal degeneration; sodium iodate ... See more keywords
Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10071125
Abstract: Oxidative damage of retinal pigment epithelium (RPE) cells plays an important role in the pathogenesis of blindness-related diseases, such as age-related macular degeneration (AMD). Quercetin, a bioactive flavonoid compound, has been shown to have a… read more here.
Keywords: reactive oxygen; oxygen species; induced retinal; sodium iodate ... See more keywords
Protective Effect of Quercetin on Sodium Iodate-Induced Retinal Apoptosis through the Reactive Oxygen Species-Mediated Mitochondrion-Dependent Pathway
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084056
Abstract: Age-related macular degeneration (AMD) leads to gradual central vision loss and is the third leading cause of irreversible blindness worldwide. The underlying mechanisms for this progressive neurodegenerative disease remain unclear and there is currently no… read more here.
Keywords: reactive oxygen; induced retinal; oxygen species; apoptosis ... See more keywords
Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG
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DOI: 10.3390/ijms23062918
Abstract: Purpose: The lack of suitable animal models for (dry) age-related macular degeneration (AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented rats and mice were systematically injected with various doses… read more here.
Keywords: injection; iodate injection; sodium iodate; retinal degenerative ... See more keywords