Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Gastric Cancer"
DOI: 10.1007/s10120-018-0874-2
Abstract: BackgroundRecent studies have described important roles for the sodium iodide symporter (NIS) in tumor behavior. The objectives of the present study were to investigate the role of NIS in the regulation of genes involved in… read more here.
Keywords: gastric cancer; analysis; expression; sodium iodide ... See more keywords
Adsorption of CO2 on sodium iodide (NaI)n (n ≤ 10) clusters: A density functional theory investigation
Sign Up to like & getrecommendations! Published in 2018 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2018.10.009
Abstract: Abstract Density functional theory (DFT) computations were carried out to investigate structural, energetic, and electronic properties of CO2 adsorbed on neutral sodium iodide clusters ((NaI)n, n = 1–10). For this purpose, the geometry of each cluster was… read more here.
Keywords: sodium iodide; functional theory; density functional; theory ... See more keywords
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00339
Abstract: Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic-pituitary-thyroid axis to potentially disrupt thyroid synthesis, transport, metabolism, and/or function. One well-known thyroid target in… read more here.
Keywords: inhibition; nis; iodide uptake; high throughput ... See more keywords
Rutin Scavenges Reactive Oxygen Species, Inactivates 5'-Adenosine Monophosphate-Activated Protein Kinase, and Increases Sodium-Iodide Symporter Expression in Thyroid PCCL3 Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Thyroid"
DOI: 10.1089/thy.2016.0585
Abstract: Background: Thyroid iodide uptake, mediated by the sodium–iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy. Therefore, compounds able to increase… read more here.
Keywords: iodide uptake; expression; pccl3; sodium iodide ... See more keywords
Dimerization of the Sodium/Iodide Symporter
Sign Up to like & getrecommendations! Published in 2019 at "Thyroid"
DOI: 10.1089/thy.2019.0034
Abstract: Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become… read more here.
Keywords: dimerization; sodium iodide; iodide symporter; nis ... See more keywords
Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Thyroid"
DOI: 10.1089/thy.2022.0163
Abstract: Background: The sodium/iodide symporter (NIS) is a transmembrane protein located on the basolateral membrane of thyrocytes. Despite its physiological and clinical relevance, little is known about the mechanisms that mediate NIS subcellular sorting. In the… read more here.
Keywords: clathrin adaptor; adaptor complexes; nis; adaptor ... See more keywords
Codoped Lithium Sodium Iodide With Tl+ and Eu2+ Activators for Neutron Detector
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Transactions on Nuclear Science"
DOI: 10.1109/tns.2019.2935725
Abstract: Investigations of high-efficiency neutron-sensitive scintillators are very important for a wide variety of applications including special nuclear material detection, fundamental research, radiation safety, and industrial monitoring, among others. Responding to this need, we have been… read more here.
Keywords: lithium sodium; iodide; codoped lithium; eu2 ... See more keywords
Evolution and developmental expression of the sodium–iodide symporter ( NIS , slc5a5) gene family: Implications for perchlorate toxicology
Sign Up to like & getrecommendations! Published in 2022 at "Evolutionary Applications"
DOI: 10.1111/eva.13424
Abstract: The vertebrate sodium–iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function by perchlorate,… read more here.
Keywords: toxicology; family; development; sodium ... See more keywords
TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0228794
Abstract: The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool,… read more here.
Keywords: nis expression; expression; sodium iodide; iodide symporter ... See more keywords
[18F]Tetrafluoroborate ([18F]TFB) and its analogs for PET imaging of the sodium/iodide symporter
Sign Up to like & getrecommendations! Published in 2018 at "Theranostics"
DOI: 10.7150/thno.24997
Abstract: Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and… read more here.
Keywords: 18f tfb; 18f tetrafluoroborate; nis; iodide ... See more keywords