Sodium oxybate for idiopathic REM sleep behavior disorder: a report on two patients.
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DOI: 10.1016/j.sleep.2016.04.014
Abstract: BACKGROUND REM-sleep behavior disorder (RBD) therapy is based on small to medium-sized case series, as no large controlled clinical trials have been performed. The most used and widely recognized effective drugs are clonazepam and melatonin,… read more here.
Keywords: behavior disorder; rem sleep; report two; two patients ... See more keywords
0743 The Pharmacokinetic Adverse Event Relationship for FT218, a Once-Nightly Sodium Oxybate Formulation
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DOI: 10.1093/sleep/zsaa056.739
Abstract: Sodium oxybate is an effective treatment for excessive daytime sleepiness and cataplexy in patients with narcolepsy. The approved formulation requires twice-nightly dosing: at bedtime and 2.5 - 4 hours later, which results in two distinct… read more here.
Keywords: adverse event; event relationship; formulation; pharmacokinetic adverse ... See more keywords
Efficacy and safety of calcium, magnesium, potassium, and sodium oxybates (lower-sodium oxybate [LXB]; JZP-258) in a placebo-controlled, double-blind, randomized withdrawal study in adults with narcolepsy with cataplexy
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DOI: 10.1093/sleep/zsaa206
Abstract: Abstract Study Objectives Evaluate efficacy and safety of lower-sodium oxybate (LXB), a novel oxybate medication with 92% less sodium than sodium oxybate (SXB). Methods Adults aged 18–70 years with narcolepsy with cataplexy were eligible. The… read more here.
Keywords: treatment; safety; sodium; efficacy ... See more keywords
487 Effect of Lower-Sodium Oxybate on Sleep Inertia in Idiopathic Hypersomnia in a Double-Blind, Randomized Withdrawal Study
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DOI: 10.1093/sleep/zsab072.486
Abstract: Idiopathic hypersomnia (IH) is a rare central hypersomnolence disorder characterized by excessive daytime sleepiness. A common feature is sleep inertia, which is prolonged difficulty waking up accompanied by confusion, disorientation, poor motor coordination, and repeated… read more here.
Keywords: sleep inertia; inertia; sodium oxybate; treatment ... See more keywords
494 Placebo-Controlled, Double-Blind, Randomized Withdrawal Study of Lower-Sodium Oxybate in Adults With Idiopathic Hypersomnia
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DOI: 10.1093/sleep/zsab072.493
Abstract: Idiopathic hypersomnia (IH) is a rare central hypersomnolence disorder characterized by excessive daytime sleepiness, prolonged nighttime sleep, and sleep inertia. No US/EU medication is approved for treatment of IH. Lower-sodium oxybate (LXB; Xywav™; previously designated… read more here.
Keywords: lxb; sodium oxybate; idiopathic hypersomnia; placebo ... See more keywords
Once-Nightly Sodium Oxybate (FT218) Demonstrated Improvement of Symptoms in a Phase 3 Randomized Clinical Trial in Patients With Narcolepsy.
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DOI: 10.1093/sleep/zsab200
Abstract: STUDY OBJECTIVES To assess the efficacy and safety of FT218, a novel once-nightly formulation of sodium oxybate (ON-SXB), in patients with narcolepsy in the phase 3 REST-ON trial. METHODS Narcolepsy patients aged ≥16 years were… read more here.
Keywords: improvement; sxb; ft218; sodium oxybate ... See more keywords
Response to: Once-nightly sodium oxybate (FT218) in the treatment of narcolepsy: a letter to the editor commenting on the recent publication by C. Kushida et al
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DOI: 10.1093/sleep/zsac042
Abstract: © Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which… read more here.
Keywords: response nightly; letter editor; sodium oxybate; nightly sodium ... See more keywords
0580 Patient Experiences With Sodium Oxybate Therapy for Narcolepsy: A Social Listening Analysis
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DOI: 10.1093/sleep/zsad077.0580
Abstract: Narcolepsy is a disorder of hypersomnolence with intermittent periods of sleep, hallucinations, and sleep paralysis. Social listening (SL) analyzes real-world data on social media to provide information on disease symptoms and impacts to inform clinicians… read more here.
Keywords: second dose; dose; sodium oxybate; social listening ... See more keywords
0591 Effectiveness and Optimization of Lower-Sodium Oxybate in Participants With Narcolepsy Switching From Sodium Oxybate (SEGUE)
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DOI: 10.1093/sleep/zsad077.0591
Abstract: Lower-sodium oxybate (LXB, Xywav®) contains 92% less sodium than higher-sodium oxybate (SXB, Xyrem®) and is approved for treating cataplexy or excessive daytime sleepiness in patients with narcolepsy (≥7 years of age) and idiopathic hypersomnia in… read more here.
Keywords: participants narcolepsy; sodium; sodium oxybate; dose regimen ... See more keywords
0598 Patient-Reported Sleep Quality in People With Narcolepsy Transitioning From Sodium Oxybate to Lower-Sodium Oxybate
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DOI: 10.1093/sleep/zsad077.0598
Abstract: Lower-sodium oxybate (LXB; Xywav®), which contains the same active moiety as higher-sodium oxybate (SXB; Xyrem®) but with 92% less sodium, is approved by the US Food and Drug Administration (FDA) for treating cataplexy or excessive… read more here.
Keywords: sodium oxybate; study; sodium; sleep quality ... See more keywords
0985 Oxybate induced mania
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DOI: 10.1093/sleep/zsad077.0985
Abstract: Hypersomnia sleep disorders are characterized by overwhelming daytime sleepiness. Treatment options include sodium oxybate the sodium salt of γ-hydroxybutyric acid (GHB). Oxybate, an endogenous metabolite of GABA, acts through GABAB noradrenergic and dopaminergic neurons, as… read more here.
Keywords: hypersomnia; oxybate; sodium oxybate; mania ... See more keywords