The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-019-09462-y
Abstract: Bufalin is the primary component of the traditional Chinese medicine “Chan Su,” which has been widely used for cancer treatment at oncology clinics in certain countries. Evidence suggests that this compound possesses potent antitumor activities,… read more here.
Keywords: bufalin; p53 signaling; glioma; sensitivity ... See more keywords
Multi‐angle development of therapeutic methods for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15174
Abstract: Recent clinical trial results support the idea that treatment based on the so‐called amyloid hypothesis is a promising approach in Alzheimer's disease (AD), but actually, developing effective treatments for AD remains highly challenging. The discovery… read more here.
Keywords: angle development; alzheimer disease; disease; multi angle ... See more keywords
Mode of Action of the Natural Insecticide, Decaleside Involves Sodium Pump Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0170836
Abstract: Decalesides are a new class of natural insecticides which are toxic to insects by contact via the tarsal gustatory chemosensilla. The symptoms of their toxicity to insects and the rapid knockdown effect suggest neurotoxic action,… read more here.
Keywords: decaleside; inhibition; mode action; sodium pump ... See more keywords
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.743824
Abstract: The sodium pump α3 subunit is associated with colorectal liver metastasis. However, the underlying mechanism involved in this effect is not yet known. In this study, we found that the expression levels of the sodium… read more here.
Keywords: expression; sodium pump; metastasis; pump ... See more keywords
Orally Administered Fumonisins Affect Porcine Red Cell Membrane Sodium Pump Activity and Lipid Profile without Apparent Oxidative Damage
Sign Up to like & getrecommendations! Published in 2020 at "Toxins"
DOI: 10.3390/toxins12050318
Abstract: Weaned piglets (n = 3 × 6) were fed 0, 15 and 30 mg/kg diet fumonisin (FB1, FB2 and FB3, i.e., FBs, a sphinganine analogue mycotoxin), from the age of 35 days for 21 days,… read more here.
Keywords: activity; pump activity; membrane; cell ... See more keywords