Discovery of a novel sodium taurocholate cotransporting polypeptide (NTCP) inhibitor: Design, synthesis, and anti-proliferative activities
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.03.017
Abstract: Abstract Sodium taurocholate cotransporting polypeptide (NTCP) is identified as the functional receptor for HBV entry, which is responsible for upregulated HBV transcription in the HBV life cycle. Besides, NTCP is also implicated in the progression… read more here.
Keywords: sodium taurocholate; ntcp inhibitor; hbv; taurocholate cotransporting ... See more keywords
The p.Ser267Phe variant of sodium taurocholate cotransporting polypeptide (NTCP) supports HBV infection with a low efficiency.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.07.006
Abstract: Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for human hepatitis B virus (HBV) and its satellite virus Hepatitis D virus (HDV). Physiologically, NTCP is responsible for the majority of sodium-dependent bile acids uptake… read more here.
Keywords: sodium taurocholate; infection; sodium; taurocholate cotransporting ... See more keywords
Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25348
Abstract: Sodium taurocholate cotransporting polypeptide (NTCP) is a major entry receptor of hepatitis B virus (HBV) and one of the most attractive targets for anti-HBV drugs. We developed a cell-mediated drug screening method to monitor NTCP… read more here.
Keywords: sodium taurocholate; taurocholate; taurocholate cotransporting; entry ... See more keywords
Clinical features of sodium-taurocholate cotransporting polypeptide deficiency in pediatric patients: case series and literature review.
Sign Up to like & getrecommendations! Published in 2021 at "Translational pediatrics"
DOI: 10.21037/tp-20-360
Abstract: Sodium-taurocholate cotransporting polypeptide (NTCP) deficiency is a newly reported hereditary bile acid metabolic disease. Here we describe the clinical characteristics of 12 cases of pediatric NTCP deficiency, as well as review 60 previously reported cases… read more here.
Keywords: sodium taurocholate; taurocholate cotransporting; ntcp deficiency; deficiency ... See more keywords
The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug metabolism"
DOI: 10.2174/1389200220666190426152830
Abstract: BACKGROUND Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts. They have emerged as promising drug… read more here.
Keywords: sodium taurocholate; transporting polypeptide; taurocholate transporting; bsep ... See more keywords
Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1147495
Abstract: The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV). Regulation of human… read more here.
Keywords: polypeptide ntcp; taurocholate cotransporting; ntcp function; sodium taurocholate ... See more keywords
NTCP polymorphisms were associated with fibrosis development in patients with chronic HBV infection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of infection in developing countries"
DOI: 10.3855/jidc.15138
Abstract: INTRODUCTION Sodium taurocholate cotransporting polypeptide has been identified as the hepatitis B virus (HBV) entry receptor. However, information regarding the role of sodium taurocholate cotransporting polypeptide variants in the development of HBV-related advanced cirrhosis and… read more here.
Keywords: taurocholate cotransporting; development; sodium taurocholate; infection ... See more keywords