Pseudo‐Pelger‐Huët neutrophil morphology due to sodium valproate toxicity
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26571
Abstract: A 57-year-old woman was referred for investigation of chronic thrombocytopenia prior to elective hip replacement. Her blood count showed haemoglobin concentration 129 g/L, MCV 96 fL, WBC 6.5 (cid:1) 10 9 /L, neutrophils 3.9 (cid:1)… read more here.
Keywords: pseudo pelger; valproate; sodium valproate; neutrophil morphology ... See more keywords
Sodium valproate modulates immune response by alternative activation of monocyte-derived macrophages in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Rheumatology"
DOI: 10.1007/s10067-017-3922-0
Abstract: The anti-inflammatory role of macrophages in apoptotic cells (ACs) clearance is involved in Systemic Lupus Erythematosus (SLE) pathogenesis. The efferocytic capability of macrophages is altered by M1/M2 polarization. Histone deacetylase inhibitors (HDACi) are proposed to… read more here.
Keywords: anti inflammatory; vpa; response; systemic lupus ... See more keywords
Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Indian Pediatrics"
DOI: 10.1007/s13312-018-1273-9
Abstract: ObjectiveTo assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH vitamin D levels in children with epilepsy compared to controls.DesignCross-sectional study.SettingOutpatient department of a tertiary-care Pediatric Neurology centre, and… read more here.
Keywords: monotherapy; ambulant children; children carbamazepine; sodium valproate ... See more keywords
Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.05.026
Abstract: Background and purpose: Diabetic patients are at greater risk for colon cancer. Histone deacetylases (HDACs) serve as common target for both. The key objective of the study was to evaluate the effect of sodium valproate… read more here.
Keywords: valproate; sodium valproate; diabetes mellitus; colon cancer ... See more keywords
Comparison of efficacy between risperidone and aripiprazole in combination with sodium valproate in patients with acute manic or mixed episodes
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.1390
Abstract: Today, despite of the improvement in the psychological therapeutic approach, mania still remains as a challenging problem for health system. The aim of this study is comparison efficacy of risperidone and aripiprazole in combination with… read more here.
Keywords: combination; combination sodium; risperidone; sodium valproate ... See more keywords
Valproate used during pregnancy: What should be done?
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.375
Abstract: Background Sodium valproate can cause serious developmental disorders in unborn babies if taken while pregnant, especially in the first trimester. Aim To review recent literature and advice or treatment for women who have or are… read more here.
Keywords: valproate used; pregnancy; valproate; used pregnancy ... See more keywords
Comprehensive study of loading and release of sodium valproate drug molecule from functionalized SBA-15 with aminopropyl groups through Co-condensation modification method
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DOI: 10.1016/j.matchemphys.2020.123622
Abstract: Abstract Mesoporous Santa Barbara amorphous (SBA-15) was functionalized through co‐condensation using tetraethoxy orthosilicate and 3-aminopropyltriethoxysilane in the presence of the copolymer Pluronic P-123 (EO20PO70EO20) as a pore‐directing agent under an acidic condition. A comprehensive study… read more here.
Keywords: comprehensive study; functionalized sba; drug; sodium valproate ... See more keywords
Epigenetic Reprogramming in Oral Epithelial Dysplasia using Sodium Valproate: an in vitro study parallel to the SAVER trial
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DOI: 10.1016/j.oooo.2021.03.109
Abstract: Background Current management of oral epithelial dysplasia (OED) focuses on preventing malignant transformation of the index lesion without addressing the risk of cancer development at other oral sites. Sodium valproate (SV) was identified as a… read more here.
Keywords: oral epithelial; sodium valproate; dysplasia; epithelial dysplasia ... See more keywords
Fanconi Syndrome Secondary to Sodium Valproate Therapy: Experience and Literature Review.
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2022.03.001
Abstract: BACKGROUND Fanconi syndrome (FS) can be of primary or secondary origin. Some cases of FS secondary to the use of sodium valproate (VPA) have been described, mostly in children with severe psychomotor retardation who are… read more here.
Keywords: psychomotor retardation; severe psychomotor; fanconi syndrome; sodium valproate ... See more keywords
Sodium valproate and clozapine induced neutropenia: A case control study using register data
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.08.041
Abstract: BACKGROUND The use of clozapine is limited due to the occurrence of neutropenia, and the rare but life threatening adverse event of agranulocytosis. There is little epidemiological research into clinical factors that may impact on… read more here.
Keywords: control study; clozapine; case; case control ... See more keywords
Evaluating the protective effects of individual or combined ginsenoside compound K and the downregulation of soluble epoxide hydrolase expression against sodium valproate-induced liver cell damage.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115555
Abstract: Sodium valproate (SVP) is one of the most commonly prescribed antiepileptic drugs. However, SVP is known to induce hepatotoxicity, which limits its clinical application for treating various neurological disorders. Previously, we found that ginsenoside compound… read more here.
Keywords: ginsenoside compound; svp induced; seh; expression ... See more keywords