Preservation of the soft protein corona in distinct flow allows identification of weakly bound proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.057
Abstract: Nanocarriers that are used for targeted drug delivery come in contact with biological liquids and subsequently proteins will adsorb to the nanocarriers' surface to form the so called 'protein corona'. The protein corona defines the… read more here.
Keywords: corona; soft corona; protein corona; soft protein ... See more keywords
In Situ Analysis of Weakly Bound Proteins Reveals Molecular Basis of Soft Corona Formation.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.0c04165
Abstract: Few experimental techniques allow the analysis of the protein corona in situ. As a result, little is known on the effects of nanoparticles on weakly bound proteins that form the soft corona. Despite its biological… read more here.
Keywords: analysis; weakly bound; formation; soft corona ... See more keywords
In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr08186k
Abstract: Methodological constraints have limited our ability to study protein corona formation, slowing nanomedicine development and their successful translation into the clinic. We determined hard and soft corona structural properties along with the corresponding proteomic compositions… read more here.
Keywords: protein; soft corona; structure; protein corona ... See more keywords
Nonconventional Phases of Colloidal Nanorods with a Soft Corona.
Sign Up to like & getrecommendations! Published in 2021 at "Physical review letters"
DOI: 10.1103/physrevlett.126.158001
Abstract: Using computer simulations, we investigate the phase behavior of hard-core spherocylinders with a length-to-diameter ratio L/σ=5 and coated by a soft deformable corona of length λ/σ=1.35. When quasi-two-dimensional layers are formed in smectic and solid… read more here.
Keywords: nonconventional phases; nanorods soft; soft corona; colloidal nanorods ... See more keywords