Palladium-Catalyzed Three-Component Coupling of 1,1-Dibromoalkenes, Vinylzinc Chloride, and Soft Nucleophiles: One-Pot Synthesis of 1,3-Disubstituted Allenes
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DOI: 10.1021/acsomega.9b03444
Abstract: The three-component coupling reaction of 1,1-dibromoalkenes 1, vinylzinc chloride 2, and carbon soft nucleophiles 3 was realized in the presence of the catalytic palladium/Xantphos species, and 1,3-disubstituted allenic products 5 were obtained in yields of… read more here.
Keywords: soft nucleophiles; component coupling; dibromoalkenes vinylzinc; three component ... See more keywords
Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp3)–H allylation of 4-alkylpyridinesâ€
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DOI: 10.1039/d0sc03304a
Abstract: We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles. This method exploits alkylidene dihydropyridines, which are semi-stable intermediates readily formed using a… read more here.
Keywords: soft nucleophiles; palladium catalyzed; anions soft; allylation alkylpyridines ... See more keywords