Inadequate health-related quality of life assessment and reporting in phase III clinical trials of immune checkpoint inhibitors in solid cancers: a systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2022.103649
Abstract: We systematically reviewed QoL assessment and reporting in RCTs of immune checkpoint inhibitors (ICIs) in solid cancers published between 2013 and 2021. None of the 106 eligible trials included QoL among primary endpoints. QoL results… read more here.
Keywords: immune checkpoint; qol results; solid cancers; assessment ... See more keywords
Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00036
Abstract: The feedback activation of the Janus kinase (JAK)-STAT pathway leads to the fact that solid cancers are not sensitive to histone deacetylase (HDAC) inhibitors. Herein, a series of novel 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitors based on… read more here.
Keywords: malignancies solid; kinase jak; hdac; solid cancers ... See more keywords
FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-86185-7
Abstract: The crosstalk between cancers and the immune microenvironment plays a critical role in malignant progression. FMS-like tyrosine kinase 3 (FLT3) is a frequently mutated gene in acute myeloid leukemia (AML). However, its role in solid… read more here.
Keywords: tertiary lymphoid; solid cancers; flt3; flt3 associated ... See more keywords
Outcome of cancer-associated venous thromboembolism is more favorable among patients with hematologic malignancies than in those with solid tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1777-4006
Abstract: BACKGROUND The natural history of patients with hematologic cancer and venous thromboembolism (VTE) has not been consistently evaluated. We aimed to compare the rates of symptomatic recurrent VTE, major bleeding or death during anticoagulant therapy… read more here.
Keywords: cancer; major bleeding; patients hematologic; venous thromboembolism ... See more keywords
Incidence of solid cancer in patients with follicular lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Acta Oncologica"
DOI: 10.1080/0284186x.2019.1643918
Abstract: Abstract Introduction: Patients with follicular lymphoma (FL) have classically had a higher risk of solid cancers than the general population, but there is little data available in patients diagnosed and treated with modern day regimens.… read more here.
Keywords: incidence solid; incidence; cancer; cancer patients ... See more keywords
Pathological point of view on the atomic bomb-related solid cancers.
Sign Up to like & getrecommendations! Published in 2025 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaf072
Abstract: Eighty years have passed since the atomic bombings (A-bombing) of Hiroshima and Nagasaki in August 1945. Survivors represent an unparalleled and irreplaceable human cohort for comprehensively studying the long-term carcinogenic effects of radiation exposure. This… read more here.
Keywords: solid cancers; pathological point; radiation; bomb radiation ... See more keywords
Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications
Sign Up to like & getrecommendations! Published in 2024 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000003090
Abstract: Abstract Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, drug resistance, and treatment outcome… read more here.
Keywords: non coding; solid cancers; long non; hematological malignancies ... See more keywords
Chest Computed Tomography-Based Radiomics and Machine Learning for Classifying Mediastinal Lymphadenopathy Caused By Hematologic Malignancies and Metastatic Abdominopelvic Solid Cancers.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of thoracic imaging"
DOI: 10.1097/rti.0000000000000860
Abstract: PURPOSE To evaluate the role of chest CT radiomics in classifying mediastinal lymphadenopathy caused by hematologic malignancies and abdominopelvic solid cancers. MATERIALS AND METHODS A total of 231 patients with mediastinal lymphadenopathy were selected from… read more here.
Keywords: solid cancers; hematologic malignancies; abdominopelvic solid; auc roc ... See more keywords
846 Neospora caninum – an immunotherapeutic protozoan against solid cancers
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0846
Abstract: Background Immunotherapy induces, provides, and/or reactivates anti-tumor immune responses. Some microorganisms also can initiate response that lyzes infected tumor and/or stimulates systemic immunity. Attenuated viruses or bacteria are well studied as oncotherapeutics, but not protozoa… read more here.
Keywords: protozoan; solid cancers; neospora caninum; cancer ... See more keywords
Natural high-avidity T-cell receptor efficiently mediates regression of cancer/testis antigen 83 positive common solid cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004713
Abstract: Background T-cell receptor-engineered T cells (TCR-Ts) have achieved encouraging success in anticancer clinical trials. The antigenic targets, however, were primarily focused on human leukocyte antigen (HLA) A*02:01 restricted epitopes from a few cancer/testis antigens (CTAs)… read more here.
Keywords: cell; cancer; high avidity; common solid ... See more keywords
Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-23-3874
Abstract: Abstract Purpose: TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus armed with TNFa and IL2, designed to induce T-cell infiltration and cytotoxicity in solid tumors. Patients and Methods: TUNIMO (NCT04695327) was a single-arm, multicenter phase I… read more here.
Keywords: tilt 123; solid cancers; 123 advanced; safety ... See more keywords