Inadequate health-related quality of life assessment and reporting in phase III clinical trials of immune checkpoint inhibitors in solid cancers: a systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2022.103649
Abstract: We systematically reviewed QoL assessment and reporting in RCTs of immune checkpoint inhibitors (ICIs) in solid cancers published between 2013 and 2021. None of the 106 eligible trials included QoL among primary endpoints. QoL results… read more here.
Keywords: immune checkpoint; qol results; solid cancers; assessment ... See more keywords
Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00036
Abstract: The feedback activation of the Janus kinase (JAK)-STAT pathway leads to the fact that solid cancers are not sensitive to histone deacetylase (HDAC) inhibitors. Herein, a series of novel 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitors based on… read more here.
Keywords: malignancies solid; kinase jak; hdac; solid cancers ... See more keywords
Outcome of cancer-associated venous thromboembolism is more favorable among patients with hematologic malignancies than in those with solid tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1777-4006
Abstract: BACKGROUND The natural history of patients with hematologic cancer and venous thromboembolism (VTE) has not been consistently evaluated. We aimed to compare the rates of symptomatic recurrent VTE, major bleeding or death during anticoagulant therapy… read more here.
Keywords: cancer; major bleeding; patients hematologic; venous thromboembolism ... See more keywords
Incidence of solid cancer in patients with follicular lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Acta Oncologica"
DOI: 10.1080/0284186x.2019.1643918
Abstract: Abstract Introduction: Patients with follicular lymphoma (FL) have classically had a higher risk of solid cancers than the general population, but there is little data available in patients diagnosed and treated with modern day regimens.… read more here.
Keywords: incidence solid; incidence; cancer; cancer patients ... See more keywords
846 Neospora caninum – an immunotherapeutic protozoan against solid cancers
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0846
Abstract: Background Immunotherapy induces, provides, and/or reactivates anti-tumor immune responses. Some microorganisms also can initiate response that lyzes infected tumor and/or stimulates systemic immunity. Attenuated viruses or bacteria are well studied as oncotherapeutics, but not protozoa… read more here.
Keywords: protozoan; solid cancers; neospora caninum; cancer ... See more keywords
Natural high-avidity T-cell receptor efficiently mediates regression of cancer/testis antigen 83 positive common solid cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004713
Abstract: Background T-cell receptor-engineered T cells (TCR-Ts) have achieved encouraging success in anticancer clinical trials. The antigenic targets, however, were primarily focused on human leukocyte antigen (HLA) A*02:01 restricted epitopes from a few cancer/testis antigens (CTAs)… read more here.
Keywords: cell; cancer; high avidity; common solid ... See more keywords
Abstract 1027: Regulatory T-cell genes drive altered immune microenvironment in adult solid cancers and allow for immune contextual patient subtyping
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1027
Abstract: The tumor microenvironment is an important factor in cancer immunotherapy response. To further understand how a tumor affects the local immune system, we analyzed immune gene expression differences between matching normal and tumor tissues. We… read more here.
Keywords: microenvironment; solid cancers; expression; gene ... See more keywords
Abstract S12-02: Risk of morbidity and mortality in COVID-19 patients with cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.covid-19-s12-02
Abstract: Introduction: Morbidity and mortality of cancer patients with COVID-19 have not been examined The goal of thisanalysis was to compare the demographics and clinical characteristics of COVID-19 cancer patients to the rest ofCOVID-19 patients and… read more here.
Keywords: patients cancer; mortality; solid cancers; non solid ... See more keywords
Extended analysis of solid cancer incidence among the Nuclear Industry Workers in the UK: 1955–2011
Sign Up to like & getrecommendations! Published in 2022 at "Radiation Research"
DOI: 10.1667/rade-20-00269.1
Abstract: Radiation worker studies provide direct estimates of cancer risk after protracted low-dose exposures to external X-ray and gamma-ray irradiations. The National Registry for Radiation Workers (NRRW) started in 1976 and has become the largest epidemiological… read more here.
Keywords: cancer; dose; radiation; solid cancer ... See more keywords
A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1116592
Abstract: Breast, ovarian, prostate, lung, and head/neck cancers are five solid cancers with complex interrelationships. However, the shared genetic factors of the five cancers were often revealed either by the combination of individual genome-wide association study… read more here.
Keywords: cancer; meta analysis; shared genetic; five solid ... See more keywords
The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11101429
Abstract: An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard, CX-5461 has been developed as a… read more here.
Keywords: combination; rna polymerase; solid cancers; cancer ... See more keywords