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   Articles with "solid dispersion" as a keyword



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Development of Fast-Dissolving Amorphous Solid Dispersion of Itraconazole by Melt Extrusion of its Mixture with Weak Organic Carboxylic Acid and Polymer

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recommendations! Published in 2018 at "Pharmaceutical Research"

DOI: 10.1007/s11095-018-2407-4

Abstract: PurposeThe purpose of this study was to explore the feasibility of developing amorphous solid dispersion (ASD) by inducing acid-base interaction at an elevated temperature using hot melt extrusion.MethodsItraconazole and glutaric acid, which do not form salt… read more here.

Keywords: melt extrusion; solid dispersion; itraconazole; amorphous solid ... See more keywords
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Improved Rapid Action of Dapoxetine Hydrochloride & L-arginine Solid Dispersion Using Film Formulation

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recommendations! Published in 2019 at "Macromolecular Research"

DOI: 10.1007/s13233-019-7047-y

Abstract: Dapoxetine Hydrochloride (DH) have been developed for the treatment of premature ejaculation for men. DH promotes the ejaculatory delay as the selective serotonin inhibitor. However, it is necessary to delay time about 1–3 hours to… read more here.

Keywords: solid dispersion; rapid action; dapoxetine hydrochloride; formulation ... See more keywords
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Comparison of solubility enhancement by solid dispersion and micronized butein and its correlation with in vivo study

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recommendations! Published in 2020 at "Journal of Pharmaceutical Investigation"

DOI: 10.1007/s40005-020-00486-9

Abstract: Purpose Even though butein can be a promising candidate for anti-inflammatory and anti-diabetic activities, it is poorly soluble limiting its availability for product development. Size reduction and solid dispersion (SD) were adopted independently to evaluate… read more here.

Keywords: solid dispersion; study; size; enhancement ... See more keywords
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Cellulose based polymers in development of amorphous solid dispersions

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recommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ajps.2018.09.003

Abstract: Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives… read more here.

Keywords: solid dispersion; solid dispersions; cellulose derivatives; cellulose based ... See more keywords
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New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug delivery system and solid dispersion.

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recommendations! Published in 2021 at "Carbohydrate polymers"

DOI: 10.1016/j.carbpol.2021.118433

Abstract: The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel dexibuprofen-loaded solid… read more here.

Keywords: dexibuprofen; solid snedds; solid dispersion; drug ... See more keywords
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Oral bioavailability enhancement of &bgr;‐lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion

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recommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"

DOI: 10.1016/j.ejpb.2017.12.016

Abstract: Graphical abstract Figure. No caption available. Abstract The aim of this paper was to compare the in vitro dissolution and in vivo bioavailability of three solubility enhancement technologies for &bgr;‐lapachone (LPC), a poorly water soluble… read more here.

Keywords: oral bioavailability; solid dispersion; bioavailability; enhancement ... See more keywords
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Self‐micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments

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recommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2016.09.015

Abstract: &NA; The present study aimed to develop an inhalable self‐micellizing solid dispersion of cyclosporine A (SMSD/CsA) for the direct delivery to the respiratory system with improved therapeutic efficacy and minimized systemic exposure. SMSD/CsA was obtained… read more here.

Keywords: solid dispersion; smsd csa; micellizing solid; self micellizing ... See more keywords
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Alginate as a potential diphase solid dispersion carrier with enhanced drug dissolution and improved storage stability

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recommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.12.028

Abstract: Abstract The objective of this study was to explore the feasibility of using alginate as a promising diphase solid dispersion carrier to enhance dissolution rate of BCS II drugs with improved stability. Taking lovastatin and… read more here.

Keywords: dissolution; solid dispersion; drug; stability ... See more keywords
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Solubilization of phloretin via steviol glycoside-based solid dispersion and micelles.

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recommendations! Published in 2019 at "Food chemistry"

DOI: 10.1016/j.foodchem.2019.125569

Abstract: In this study, the solubility of phloretin (PT) was enhanced via steviol glycoside (STE)-based micelle (MC) and solid dispersion (SD). Computer simulation, characterization, interaction with serum albumin (SA) and in vitro release were carried out… read more here.

Keywords: ste; phloretin; via steviol; solid dispersion ... See more keywords
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Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization.

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recommendations! Published in 2017 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.01.018

Abstract: The present study aimed to develop an amorphous solid dispersion (ASD) of cyclosporine A (CsA) by a fine droplet drying (FDD) process for improvement in oral absorption of CsA. CsA and hydroxypropyl cellulose-SSL were dissolved… read more here.

Keywords: droplet drying; solid dispersion; amorphous solid; asd csa ... See more keywords
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From benchtop to pilot scale-experimental study and computational assessment of a hot-melt extrusion scale-up of a solid dispersion of dipyridamole and copovidone.

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recommendations! Published in 2018 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.12.033

Abstract: The aim of our work was to study and define a computationally-based adiabatic scale-up methodology for a hot-melt extrusion (HME) process to produce an amorphous solid dispersion (ASD). As a drug product becomes commercially viable,… read more here.

Keywords: melt extrusion; solid dispersion; hot melt; dipyridamole copovidone ... See more keywords