Thermal analysis study of solid dispersions hydrochlorothiazide
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DOI: 10.1007/s10973-017-6091-0
Abstract: Solid dispersions (SD) are used as a technological strategy to increase the aqueous dissolution rate of poorly soluble active pharmaceutical ingredients, such as hydrochlorothiazide (HCTZ), an antihypertensive used frequently in medical clinics. The aim of… read more here.
Keywords: analysis; thermal analysis; solid dispersions; analysis study ... See more keywords
Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid Dispersions
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DOI: 10.1007/s11095-017-2316-y
Abstract: PurposeThe oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid dispersions (ASDs) where the API is dissolved in polymeric excipients. Desired properties of such ASDs like… read more here.
Keywords: low molecular; solid dispersions; molecular weight; amorphous solid ... See more keywords
Cellulose based polymers in development of amorphous solid dispersions
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DOI: 10.1016/j.ajps.2018.09.003
Abstract: Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives… read more here.
Keywords: solid dispersion; solid dispersions; cellulose derivatives; cellulose based ... See more keywords
Interfacial interaction track of amorphous solid dispersions established by water‐soluble polymer and indometacin
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DOI: 10.1016/j.ejps.2017.05.067
Abstract: Abstract The present work studied interfacial interactions of amorphous solid dispersions matrix of indometacin (IMC) that established using PVP K30 (PVP) and PEG 6000 (PEG) by focusing on their interaction forces and wetting process. Infrared… read more here.
Keywords: contact angle; water; solid dispersions; amorphous solid ... See more keywords
Effect of polymer type on the surface energy of acetaminophen solid dispersions prepared by melt method.
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DOI: 10.1016/j.ijpharm.2017.07.029
Abstract: Many newly developed active pharmaceutical ingredients (APIs) have very low solubility in aqueous media. The preparation of solid dispersions (SDs) is one way of avoiding this problem. However, compound wettability and thus solubility are influenced… read more here.
Keywords: effect polymer; surface; solid dispersions; prepared melt ... See more keywords
Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus® processed by hot melt extrusion.
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DOI: 10.1016/j.ijpharm.2017.09.035
Abstract: The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus® polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was achieved… read more here.
Keywords: melt extrusion; solid dispersions; hpmcp soluplus; hot melt ... See more keywords
Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions
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DOI: 10.1016/j.ijpharm.2018.11.015
Abstract: Graphical abstract Figure. No caption available. Abstract Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many… read more here.
Keywords: fluid assisted; solid dispersions; carv; supercritical fluid ... See more keywords
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings
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DOI: 10.1016/j.ijpharm.2019.01.009
Abstract: &NA; Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high melting points, thermal stability limitations, or poor solubility in volatile solvents, conventional routes of hot… read more here.
Keywords: solid dispersions; drug; amorphous solid; particle ... See more keywords
The roles of a surfactant in zein‐HPMC blend solid dispersions for improving drug delivery
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DOI: 10.1016/j.ijpharm.2019.04.009
Abstract: Graphical abstract Figure. No caption available. ABSTRACT This study aimed to originally investigate the roles of a surfactant in hydrophilic‐hydrophobic polymer blend solid dispersions (SDs) to enhance drug dissolution. Different formulations of SDs containing a… read more here.
Keywords: blend solid; solid dispersions; drug; roles surfactant ... See more keywords
Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in-vitro approach.
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DOI: 10.1016/j.ijpharm.2019.04.034
Abstract: Several drugs are pH-dependent soluble weak bases with a poor solubility in the intestinal pH range. Additionally a variable gastric pH, which is a common issue in the population, potentially reduces the in-vivo performance due… read more here.
Keywords: dependent soluble; gastric variability; weak bases; solid dispersions ... See more keywords
Electrospun amorphous solid dispersions of meloxicam: influence of polymer type and downstream processing to orodispersible dosage forms.
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DOI: 10.1016/j.ijpharm.2019.118593
Abstract: The objectives of this work were to develop meloxicam based amorphous solid dispersion through electrospinning technique and evaluate the effect of the polymeric matrix on the physicochemical properties of the fibers and the downstream processing… read more here.
Keywords: downstream processing; solid dispersions; amorphous solid; dosage forms ... See more keywords