Design and optimization of metformin solid lipid microparticles for topical application
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Lipid Science and Technology"
DOI: 10.1002/ejlt.202300221
Abstract: This study aimed to improve metformin skin administration by creating solid lipid microparticles (SLMs). To obtain optimal metformin delivery, SLMs were created using a double emulsion hot homogenization technique with a rotor‐stator. The effects of… read more here.
Keywords: release; drug; lipid microparticles; metformin solid ... See more keywords
Impact of solid lipid nanoparticles on 3T3 fibroblasts viability and lipid profile: The effect of curcumin and resveratrol loading
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4379
Abstract: This study focused on the impact in 3T3 fibroblasts of several types of empty and curcumin‐ and resveratrol‐loaded solid lipid nanoparticles (SLN) on cell viability and lipid metabolism in relation to their lipid content and… read more here.
Keywords: resveratrol; solid lipid; 3t3 fibroblasts; curcumin ... See more keywords
Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4434
Abstract: Curcumin, one of the three principal curcuminoids found within turmeric rhizomes, has long been associated with numerous physiologically beneficial effects; however, its efficacy is limited by its inherently low bioavailability. Several novel formulations of curcumin… read more here.
Keywords: particle preparation; solid lipid; curcumin; curcumin particle ... See more keywords
Enhanced Cytotoxic Effects of Docetaxel‐Loaded Solid Lipid Nanoparticles (SLN‐DTX) on Gastric Adenocarcinoma In Vitro
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70456
Abstract: Gastric cancer is one of the leading causes of mortality worldwide. Despite recent advances in cancer therapy, there has been little change in cure and survival rates in patients suffering from gastric cancer. The use… read more here.
Keywords: cancer; gastric adenocarcinoma; sln dtx; solid lipid ... See more keywords
On the Structure of Solid Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201903156
Abstract: Solid lipid nanoparticles (SLNs) have a crystalline lipid core which is stabilized by interfacial surfactants. SLNs are considered favorable candidates for drug delivery vehicles since their ability to store and release organic molecules can be… read more here.
Keywords: drug; structure; structure solid; lipid nanoparticles ... See more keywords
Design and Preparation of Solid Lipid Nanoparticle (SLN)-Mediated DNA Vaccines.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1892-9_18
Abstract: Increasing application of nucleic acid vaccines is driving demand for new delivery systems to improve stability and efficacy of DNA vaccines. Solid lipid nanoparticles (SLN) are a particulate carrier system composed of a solid lipid… read more here.
Keywords: dna; design preparation; dna vaccines; solid lipid ... See more keywords
Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01731-1
Abstract: The aim of this present study was to evaluate the effect of solid lipid nanoparticles (SLN) containing carvacrol over the lung damage of airway smoke inhalation. The study was conducted with 30 rats subjected to… read more here.
Keywords: smoke inhalation; control; inhalation; carvacrol ... See more keywords
Ultrastructural changes on fertile and infertile hydatid cysts induced by conventional and solid lipid nanoparticles of albendazole and albendazole sulfoxide
Sign Up to like & getrecommendations! Published in 2019 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-019-02925-y
Abstract: Cystic echinococcosis (CE), a serious public health problem worldwide, is caused by the larval stage of Echinococcus granulosus (E. granulosus). Despite recent progress in the CE medical treatment, this subject still remains as a priority… read more here.
Keywords: albendazole sulfoxide; hydatid cysts; fertile infertile; lipid nanoparticles ... See more keywords
Screening of Selective C16 to C18 Lipids and Process Optimization Based on Design of Experiments in Formulating Solid Lipid Microparticles by Twin Screw Hot Melt Dispersion Process
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-021-09575-0
Abstract: Long-acting solid lipid microparticles of tetracycline hydrochloride (TH) were prepared using solvent-free twin screw hot melt dispersion technique utilizing biocompatible lipids. Design of experiments was employed to assess the formulation and process parameters followed by… read more here.
Keywords: diffusion; drug; process; solid lipid ... See more keywords
Simvastatin-Loaded PEGylated Solid Lipid Nanoparticles: Lipid Functionalization to Improve Blood Circulation
Sign Up to like & getrecommendations! Published in 2020 at "BioNanoScience"
DOI: 10.1007/s12668-020-00770-w
Abstract: The aim of the present work was to formulate simvastatin-loaded PEGylated solid lipid nanoparticles (PEG-SLNs) for prolonging blood circulation. Plain solid lipid nanoparticles (P-SLNs) were prepared by ethanol injection method. Prepared P-SLNs were PEGylated using… read more here.
Keywords: peg slns; simvastatin; slns; lipid nanoparticles ... See more keywords
The in vivo toxicological profile of cationic solid lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-019-00657-8
Abstract: Cationic solid lipid nanoparticles (cSLNs) are considered as one of the most effective lipid nanocarriers for delivery of low water-solubility compounds and genetic materials. As the excipients used in the cSLN production are generally regarded… read more here.
Keywords: toxicological profile; cationic solid; lipid nanoparticles; vivo toxicological ... See more keywords