Articles with "solid phase" as a keyword



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Chemically functionalized silica nanoparticles‐based solid‐phase extraction for effective pre‐concentration of highly toxic metal ions from food and water samples

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Published in 2018 at "Applied Organometallic Chemistry"

DOI: 10.1002/aoc.4012

Abstract: In this research study, an efficient solid-phase extraction procedure based on a new organometallic, effective, eco-friendly and bio-degradable nanoadsorbent was firstly introduced for influential pre-concentration of Cu(II), Zn(II), Pb(II), Cd(II) and Mn(II) ions from food… read more here.

Keywords: pre concentration; extraction; food water; solid phase ... See more keywords
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Efficient solid‐phase synthesis of acetylated lignin and a comparison of the properties of different modified lignins

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Published in 2017 at "Journal of Applied Polymer Science"

DOI: 10.1002/app.44276

Abstract: The chemical modification of lignin can greatly enhance its functionality and exploit its application areas. To avoid the difficulties of separation and environmental pollution in the traditional liquid-phase method, we prepared acetylated lignin by a… read more here.

Keywords: phase synthesis; phase; efficient solid; solid phase ... See more keywords
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Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies.

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Published in 2018 at "Biotechnology journal"

DOI: 10.1002/biot.201700381

Abstract: Antibodies are synthesized in mammalian cell culture as heterogeneous mixtures of glycoforms. Production of single glycoforms remains a challenge despite their value as therapeutics. The authors report a method of sequential enzymatic-based changes to antibodies… read more here.

Keywords: produces high; phase; enzymatic remodeling; solid phase ... See more keywords
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Solid‐Phase Synthesis and Application of a Clickable Version of Epoxomicin for Proteasome Activity Analysis

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Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202100710

Abstract: Degradation of proteins by the proteasome is an essential cellular process and one that many wish to study in a variety of disease types. There are commercially available probes that can monitor proteasome activity in… read more here.

Keywords: proteasome activity; activity; application clickable; synthesis application ... See more keywords
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Facile de Novo Sequencing of Tetrazine‐Cyclized Peptides through UV‐Induced Ring‐Opening and Cleavage from the Solid Phase

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Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200590

Abstract: While most FDA‐approved peptide drugs are cyclic, the robust cyclization chemistry of peptides and the deconvolution of cyclic peptide sequences by using tandem mass spectrometry render cyclic peptide drug discovery difficult. Here we present the… read more here.

Keywords: sequencing tetrazine; cyclic peptides; novo sequencing; solid phase ... See more keywords
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Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors

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Published in 2020 at "ChemMedChem"

DOI: 10.1002/cmdc.201900659

Abstract: More than 160 arginine analogues modified on the C‐terminus via either an amide bond or a heterocyclic moiety (1,2,4‐oxadiazole, 1,3,4‐oxadiazole and 1,2,4‐triazole) were prepared as potential inhibitors of NO synthases (NOS). A methodology involving formation… read more here.

Keywords: phase synthesis; substrate based; based dipeptides; synthesis substrate ... See more keywords
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A High‐Throughput Process for the Solid‐Phase Purification of Synthetic DNA Sequences

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Published in 2017 at "Current Protocols in Nucleic Acid Chemistry"

DOI: 10.1002/cpnc.31

Abstract: An efficient process for the purification of synthetic phosphorothioate and native DNA sequences is presented. The process is based on the use of an aminopropylated silica gel support functionalized with aminooxyalkyl functions to enable capture… read more here.

Keywords: dna sequences; dna; solid phase; process ... See more keywords
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Novel Aryl Boronate Ester Based Amino Acids as Orthogonal Building Blocks for Fmoc Solid Phase Peptide Synthesis

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Published in 2017 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.201701064

Abstract: Three novel aryl boronate ester based amino acids are described. These useful building blocks were found to exhibit all of the chemical properties compatible to the Fmoc strategy solid-phase peptide synthesis and orthogonal to Boc,… read more here.

Keywords: novel aryl; solid phase; peptide synthesis; phase peptide ... See more keywords
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Synthesis of C ‐Glycosyl Amino Acid Building Blocks Suitable for the Solid‐Phase Synthesis of Multivalent Glycopeptide Mimics

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Published in 2020 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202000587

Abstract: Five C-glycosyl functionalized lysine building blocks, featuring C-glycosidic derivatives of alpha-rhamnose, alpha-mannose, alpha-galactose, beta-galactose, and beta-N-acetyl glucosamine have been designed and synthesized. These derivatives, equipped with acid-labile protecting groups, are eminently suitable for solid-phase synthesis… read more here.

Keywords: suitable solid; solid phase; synthesis; building blocks ... See more keywords
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Molecularly imprinted solid‐phase extraction coupled with LC–APCI–MS–MS for the selective determination of serum cholesterol

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Published in 2017 at "ELECTROPHORESIS"

DOI: 10.1002/elps.201600489

Abstract: The assessment of selective molecularly imprinted solid‐phase extraction (MISPE) for clean‐up and extraction of cholesterol (CHO) from bovine and human serum samples was evaluated. Two molecular imprinted polymers (MIP) based on organic and inorganic/organic (hybrid)… read more here.

Keywords: phase; extraction; solid phase; serum ... See more keywords
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A carbon nanoparticles‐based solid‐phase purification method facilitating sensitive MALDI–MS analysis of permethylated N‐glycans

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Published in 2018 at "ELECTROPHORESIS"

DOI: 10.1002/elps.201800254

Abstract: In recent decades, MALDI–MS has been extensively used for the analysis of glycans. However, native glycans usually have low ionization efficiency in MS, which hinders the direct analysis. Permethylation of glycans is a solution for… read more here.

Keywords: phase purification; analysis; carbon; solid phase ... See more keywords