Polymeric Precipitation Inhibitor–Based Solid Supersaturable SMEDD Formulation of Canagliflozin: Improved Bioavailability and Anti-diabetic Activity
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DOI: 10.1007/s12247-020-09445-1
Abstract: Purpose The current investigation explores the enhanced biopharmaceutical attributes of solid supersaturable self-microemulsifying drug delivery system (Solid SS SMEDDS) for poorly water soluble drug canagliflozin (CFZ). Methods Solid SS SMEDD formulation was prepared by spray drying… read more here.
Keywords: solid supersaturable; precipitation inhibitor; smedd formulation; formulation ... See more keywords
Development, characterization, comparative pharmacokinetic and pharmacodynamic studies of iloperidone solid SMEDDS and liquisolid compact
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DOI: 10.1080/03639045.2020.1742142
Abstract: Abstract Iloperidone (ILO) is an anti-psychotic, used in schizophrenia. It has low bioavailability (36%) due to low solubility and first pass effect. Oral solid self microemulsifying drug delivery system (SMEDDS) and liquisolid compact (LSC) of… read more here.
Keywords: liquisolid compact; development characterization; smedds liquisolid; solid smedds ... See more keywords
Design, Characterization, and Evaluation of Diosmetin-Loaded Solid Self-microemulsifying Drug Delivery System Prepared by Electrospray for Improved Bioavailability
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DOI: 10.1208/s12249-022-02263-3
Abstract: Diosmetin (DIOS) is a functional compound with poor water solubility, bad permeability, and crystal form. Self-microemulsifying drug delivery system (SMEDDS) was an effective formulation to overcome these shortcomings. In this study, liquid SMEDDS was prepared… read more here.
Keywords: loaded solid; self microemulsifying; solid smedds; bioavailability ... See more keywords
Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug Dissolution and In vivo Effects—a Pharmacokinetic and Pharmacodynamic Assessment
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DOI: 10.1208/s12249-022-02272-2
Abstract: Lovastatin (Lov) is a lipid-lowering agent, with 5% bioavailability (BA) due to extensive first pass metabolism and poor solubility. To enhance dissolution and in vivo effects, Lov solid self microemulsifying drug delivery system (SMEDDS) and… read more here.
Keywords: smedds liquisolid; dissolution; vivo effects; solid smedds ... See more keywords
Cationic Solid SMEDDS of Efavirenz for Improved Oral Delivery: Development by Central Composite Design, In Vitro and In Vivo Evaluation
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DOI: 10.1208/s12249-022-02495-3
Abstract: Efavirenz (EFV) is an anti-HIV drug with high dose and 40% oral bioavailability (BA). The aim was to improve the bioavailability by designing cationic solid SMEDDS. Solubility data, ternary phase diagrams, and central composite design… read more here.
Keywords: solid smedds; smedds; central composite; cationic solid ... See more keywords