Advances and Challenges in Human 3D Solid Tumor Models
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202419912
Abstract: The field of cancer biology and therapeutics has soared in the past several decades with new therapeutic modalities and options for patients, such as chemoradiotherapy, immunotherapy, and combination therapy. This dramatic success in expanding patient… read more here.
Keywords: cancer; tumor models; biology; advances challenges ... See more keywords
Inhibitory Microenvironment Remodeling Enhances STING Activation for Solid Tumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202421849
Abstract: The immunomodulatory effect of the interferon gene‐stimulating factor (STING) pathway makes it an important target for tumor immunotherapy, which, however, suffers from the easy degradation and deteriorated stimulatory capacity of current STING agonists in the… read more here.
Keywords: tumor immunotherapy; microenvironment; sting agonists; tumor ... See more keywords
An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity.
Sign Up to like & getrecommendations! Published in 2024 at "Advanced materials"
DOI: 10.1002/adma.202411454
Abstract: Hematopoietic progenitor pinase1 (HPK1) knockout has been identified as an efficient route to enhance anti-tumor immune response. Here, this work develops an oral proteolysis targeting chimera (PROTAC) targeting HPK1 to efficiently and selectively degrade HPK1… read more here.
Keywords: protac; protac targeting; targeting hpk1; tumor ... See more keywords
Enhancing Penetration Ability of Semiconducting Polymer Nanoparticles for Sonodynamic Therapy of Large Solid Tumor
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104125
Abstract: Sonodynamic therapy (SDT) holds growing promise in deep‐seated or large solid tumor treatment owing to its high tissue penetration depth ability; however, its therapeutic efficacy is often compromised due to the hypopermeable and hypoxic characteristics… read more here.
Keywords: tumor; penetration; solid tumor; large solid ... See more keywords
Spatiotemporally Controlled T‐Cell Combination Therapy for Solid Tumor
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DOI: 10.1002/advs.202401100
Abstract: Due to multidimensional complexity of solid tumor, development of rational T‐cell combinations and corresponding formulations is still challenging. Herein, a triple combination of T cells are developed with Indoleamine 2,3‐dioxygenase inhibitors (IDOi) and Cyclin‐dependent kinase… read more here.
Keywords: combination; controlled cell; tumor; cell ... See more keywords
The link between psychological distress and survival in solid tumor patients: A systematic review
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5200
Abstract: Research has demonstrated that solid tumor patients experience high levels of psychological distress at the time of diagnosis. While distress has been associated with many adverse clinical outcomes, little is known about how this symptom… read more here.
Keywords: survival; psychological distress; solid tumor; tumor patients ... See more keywords
A nomogram prediction of citrate reaction during mononuclear cell collection in solid tumor patients.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical apheresis"
DOI: 10.1002/jca.22042
Abstract: PURPOSE Citrate reaction is one of the main adverse events in peripheral blood mononuclear cell (MNC) collection. The aim of this study was to elucidate the risk factors for citrate reaction in patients with advanced… read more here.
Keywords: citrate reaction; risk; solid tumor; blood ... See more keywords
Solid tumor size for prediction of recurrence in large and giant non-functioning pituitary adenomas
Sign Up to like & getrecommendations! Published in 2021 at "Neurosurgical Review"
DOI: 10.1007/s10143-021-01662-7
Abstract: A subset of large non-functioning pituitary adenomas (lNFPA) and giant non-functioning pituitary adenomas (gNFPA) undergoes early progression/recurrence (P/R) after surgery. This study revealed the clinical and image predictors of P/R in lNFPA and gNFPA, with… read more here.
Keywords: non functioning; solid tumor; pituitary adenomas; functioning pituitary ... See more keywords
Mechanisms of Efficacy of the FGFR1–3 Inhibitor AZD4547 in Pediatric Solid Tumor Models
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DOI: 10.1007/s10637-020-00933-2
Abstract: Children with aggressive pediatric solid tumors have poor outcomes and novel treatments are needed. Pediatric solid tumors demonstrate aberrant expression and activity of the fibroblast growth factor receptor (FGFR) family, suggesting FGFR inhibitors may be… read more here.
Keywords: pediatric solid; inhibitor; solid tumor; efficacy ... See more keywords
Overcoming biological barriers to improve solid tumor immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-00923-8
Abstract: Cancer immunotherapy has been at the forefront of therapeutic interventions for many different tumor types over the last decade. While the discovery of immunotherapeutics continues to occur at an accelerated rate, their translation is often… read more here.
Keywords: tumor immunotherapy; tumor; biological barriers; solid tumor ... See more keywords
Estimation of radiation-induced organ-specific secondary solid tumor occurrence rates with total body irradiation and total marrow irradiation treatments.
Sign Up to like & getrecommendations! Published in 2020 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2020.03.006
Abstract: PURPOSE/OBJECTIVE(S) We aimed to predict and compare radiation-induced organ-specific secondary solid tumor occurrence risks from conventional total body irradiation (TBI) and from total marrow irradiation (TMI) for patients undergoing hematopoietic cell transplant (HCT). MATERIALS/METHODS We… read more here.
Keywords: secondary solid; irradiation; radiation induced; solid tumor ... See more keywords