Prospective Comparison of Medical Oncologists and a Machine Learning Model to Predict 3-Month Mortality in Patients With Metastatic Solid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.14514
Abstract: Key Points Question How do oncologists and a machine learning model compare in predicting 3-month mortality for patients with advanced solid tumors? Findings In this prognostic study, the machine learning model significantly outperformed 74 oncologists… read more here.
Keywords: learning model; machine learning; solid tumors; month mortality ... See more keywords
Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor-Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors: A Phase 1/2a Dose-Escalation and Cohort-Expansion Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.3848
Abstract: Importance Multiple immunostimulatory agonist antibodies have been clinically tested in solid tumors to evaluate the role of targeting glucocorticoid-induced tumor necrosis factor (TNF) receptor-related protein in anticancer treatments. Objective To evaluate the safety and activity… read more here.
Keywords: combination; solid tumors; safety; bms 986156 ... See more keywords
Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.1467
Abstract: Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors In a previous cohort study, administration of the BNT162b2 vaccine in patients with solid tumors demonstrated a favorable safety and efficacy profile following the second… read more here.
Keywords: patients solid; vaccine patients; immunogenicity; solid tumors ... See more keywords
Impact of chemotherapy and/or immunotherapy on neutralizing antibody response to SARS‐CoV‐2 mRNA‐1237 vaccine in patients with solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13359
Abstract: Patients with solid tumors have been a risk group since the beginning of the SARS‐CoV‐2 pandemic due to more significant complications, hospitalizations or deaths. The immunosuppressive state of cancer treatments or the tumor itself could… read more here.
Keywords: patients solid; mrna 1237; chemotherapy immunotherapy; solid tumors ... See more keywords
G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
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DOI: 10.1002/2211-5463.13445
Abstract: There are two types of abnormal hematopoiesis in solid tumor occurrence and treatment: pathological hematopoiesis, and myelosuppression induced by radiotherapy and chemotherapy. In this review we primarily focus on the abnormal pathological hematopoietic differentiation in… read more here.
Keywords: csf; csf induced; csf csf; hematopoiesis ... See more keywords
The Efficacy of Nanoparticle Delivery to Hypoxic Solid Tumors by ciRGD Co-administration Depends on Neuropilin-1 and Neutrophil Levels.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300594
Abstract: The ability to improve nanoparticle delivery to solid tumors is an actively studied domain, where various mechanisms have been looked into. In previous work, w e have looked into nanoparticle size, tumor vessel normalization and… read more here.
Keywords: neutrophil levels; nanoparticle delivery; cirgd administration; solid tumors ... See more keywords
Multifunctional Biomimetic Nanovaccines Based on Photothermal and Weak‐Immunostimulatory Nanoparticulate Cores for the Immunotherapy of Solid Tumors
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DOI: 10.1002/adma.202108012
Abstract: An alternative strategy of choosing photothermal and weak‐immunostimulatory porous silicon@Au nanocomposites as particulate cores to prepare a biomimetic nanovaccine is reported to improve its biosafety and immunotherapeutic efficacy for solid tumors. A quantitative analysis method… read more here.
Keywords: weak immunostimulatory; nanoparticulate cores; solid tumors; photothermal weak ... See more keywords
A Peritumorally Injected Immunomodulating Adjuvant Elicits Robust and Safe Metalloimmunotherapy against Solid Tumors
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DOI: 10.1002/adma.202206915
Abstract: Clinical immunotherapy of solid tumors elicits durable responses only in a minority of patients, largely due to the highly immunosuppressive tumor microenvironment (TME). Although rational combinations of vaccine adjuvants with inflammatory cytokines or immune agonists… read more here.
Keywords: peritumorally injected; metalloimmunotherapy solid; tumor; elicits robust ... See more keywords
Genetically Programmable Vesicles for Enhancing CAR‐T Therapy against Solid Tumors
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202211138
Abstract: Chimeric antigen receptor‐T (CAR‐T) cell therapy has shown remarkable success in eradicating hematologic malignancies; however, its efficacy in treating solid tumors has always been limited due to the presence of an immune‐suppressive tumor microenvironment (TME).… read more here.
Keywords: tumor; apd nvs; car; genetically programmable ... See more keywords
Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors
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DOI: 10.1002/cac2.12394
Abstract: Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell adoptive immunotherapy in humans has shown modest efficacy. In… read more here.
Keywords: natural killer; killer cells; immune checkpoints; solid tumors ... See more keywords
Phase 1 trial of ADI‐PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4446
Abstract: Arginine depletion interferes with pyrimidine metabolism and DNA damage repair pathways. Preclinical data demonstrated that depletion of arginine by PEGylated arginine deiminase (ADI‐PEG 20) enhanced liposomal doxorubicin (PLD) cytotoxicity in cancer cells with argininosuccinate synthase… read more here.
Keywords: liposomal doxorubicin; solid tumors; adi peg; metastatic solid ... See more keywords