Single-cell analysis on stromal fibroblasts in the microenvironment of solid tumours.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2019.12.001
Abstract: Besides malignant cells, the tumour microenvironment consists of various stromal cells such as cancer-associated fibroblasts (CAFs) and myofibroblasts. Accumulation of heterogeneous populations of stromal cells in solid tumours is associated with lower survival rates and… read more here.
Keywords: single cell; fibroblasts microenvironment; stromal fibroblasts; cancer ... See more keywords
Influenza vaccination in adult patients with solid tumours treated with chemotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.02.012
Abstract: Patients with solid tumours receiving chemotherapy are at risk for influenza complications. Yearly influenza vaccination is recommended to patients treated with chemotherapy. However, adherence to vaccination is low, most likely due to lack of data… read more here.
Keywords: chemotherapy; solid tumours; influenza vaccination; vaccination ... See more keywords
First-in-human phase I study of oral S49076, a unique MET/AXL/FGFR inhibitor, in advanced solid tumours.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.05.007
Abstract: BACKGROUND AND OBJECTIVES S49076 is a novel ATP-competitive tyrosine kinase inhibitor of MET, AXL and FGFR with a unique selectivity profile. A phase I open-label study was undertaken to establish the tolerability profile and determine… read more here.
Keywords: phase; axl fgfr; advanced solid; s49076 ... See more keywords
A first-in-human phase I study of SAR125844, a selective MET tyrosine kinase inhibitor, in patients with advanced solid tumours with MET amplification.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.10.016
Abstract: PURPOSE Dysregulated MET signalling is implicated in oncogenesis. The safety and preliminary efficacy of a highly selective MET kinase inhibitor (SAR125844) was investigated in patients with advanced solid tumours and MET dysregulation. METHODS This was… read more here.
Keywords: met amplification; kinase inhibitor; selective met; patients advanced ... See more keywords
Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials.
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DOI: 10.1016/j.ejca.2018.06.003
Abstract: BACKGROUND Adolescent and young adult (AYA) patients with advanced solid tumours are often considered for phase I clinical trials with novel agents. The outcome of AYAs in these trials have not been described before. AIM… read more here.
Keywords: advanced solid; aya patients; phase trials; cancer ... See more keywords
Heterogeneity of hypoxia in solid tumours and mechanochemical reactions with oxygen nanobubbles.
Sign Up to like & getrecommendations! Published in 2017 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2017.03.006
Abstract: Tumour hypoxia leads to radio and chemotherapy resistance among cancer patients. The aim of this paper is to formulate a hypothesis on the heterogeneity of hypoxia in solid tumours. Tumour vasculature is known to be… read more here.
Keywords: hypoxia solid; oxygen; heterogeneity; heterogeneity hypoxia ... See more keywords
Cancer: Redirecting T cell activity in solid tumours
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2018.214
Abstract: Promoting NAD+ production Accumulating evidence indicates that NAD — a coenzyme for several enzymes, with a critical role in mitochondrial energy production — confers protection against ageing and numerous diseases. Using Caenorhabditis elegans and cell… read more here.
Keywords: cancer redirecting; redirecting cell; activity solid; cell activity ... See more keywords
Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours
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DOI: 10.1038/s41568-019-0169-x
Abstract: The spectrum of tumours arising in childhood is fundamentally different from that seen in adults, and they are known to be divergent from adult malignancies in terms of cellular origins, epidemiology, genetic complexity, driver mutations… read more here.
Keywords: characteristics therapeutic; therapeutic vulnerabilities; vulnerabilities across; paediatric solid ... See more keywords
Invasive pulmonary aspergillosis in patients with solid tumours: risk factors and predictors of clinical outcomes
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DOI: 10.1080/07853890.2018.1518581
Abstract: Abstract Background: The characteristics and management of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies are well known, but IPA in patients with solid tumours is not well described. Methods: We retrospectively reviewed all… read more here.
Keywords: pulmonary aspergillosis; risk factors; invasive pulmonary; solid tumours ... See more keywords
Broad reactivity and enhanced potency of recombinant anti-EGFR × anti-CD3 bispecific antibody-armed activated T cells against solid tumours
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2059101
Abstract: Abstract Introduction: Bispecific antibody (BiAb)-armed activated T cells (BATs) comprise an adoptive T cell therapy platform for treating cancer. Arming activated T cells (ATC) with anti-CD3 x anti-tumour associated antigen (TAA) BiAbs converts ATC into… read more here.
Keywords: activated cells; bispecific antibody; solid tumours; anti cd3 ... See more keywords
90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours
Sign Up to like & getrecommendations! Published in 2022 at "Nanotechnology"
DOI: 10.1088/1361-6528/ac7ac0
Abstract: Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated with citrate, dextran… read more here.
Keywords: hyperthermia; solid tumours; 90y spions; radionuclide ... See more keywords