Overcoming the Challenges of Low Drug Solubility in the Intravenous Formulation of Solithromycin.
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DOI: 10.1016/j.xphs.2017.10.030
Abstract: Solithromycin is a fluoro-ketolide (a fourth-generation macrolide) antibiotic that has been undergoing clinical trials for the treatment of community-acquired bacterial pneumonia. In this study, development of the tri-amino acid-buffered solithromycin intravenous (IV) formulation was performed… read more here.
Keywords: buffered formulation; solithromycin; formulation; overcoming challenges ... See more keywords
Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects
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DOI: 10.1093/jac/dkw428
Abstract: Background Macrolide antibiotics may cause QT prolongation. Objectives To study the QT effect of a novel macrolide, solithromycin. Methods This was a thorough QT study with a three-way crossover design performed in healthy male and… read more here.
Keywords: solithromycin; three way; study; novel macrolide ... See more keywords
Solithromycin: A novel ketolide antibiotic
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DOI: 10.2146/ajhp160934
Abstract: Purpose The pharmacology, pharmacokinetics, pharmacodynamics, antimicrobial activity, clinical safety, and current regulatory status of solithromycin are reviewed. Summary Solithromycin is a novel ketolide antibiotic developed for the treatment of community‐acquired bacterial pneumonia (CABP). Its pharmacologic,… read more here.
Keywords: solithromycin novel; solithromycin; ketolide antibiotic; novel ketolide ... See more keywords