Enantioseparation of solriamfetol and its major impurity phenylalaninol by capillary electrophoresis using sulfated gamma cyclodextrin
Sign Up to like & getrecommendations! Published in 2021 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202100076
Abstract: R‐solriamfetol is a recently approved drug used for the treatment of excessive sleepiness associated with narcolepsy and sleep apnea. Herein, a capillary electrophoretic method was developed, enabling the simultaneous analysis of the API and its… read more here.
Keywords: impurity phenylalaninol; electrophoresis; major impurity; solriamfetol ... See more keywords
Solriamfetol: First Global Approval
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DOI: 10.1007/s40265-019-01123-y
Abstract: Solriamfetol (Sunosi™) is an orally active, selective dopamine and norepinephrine reuptake inhibitor that was recently approved in the USA as a treatment for excessive daytime sleepiness (hypersomnia) associated with narcolepsy and obstructive sleep apnoea (OSA).… read more here.
Keywords: solriamfetol first; global approval; sleepiness; solriamfetol ... See more keywords
Study protocol and rationale for a randomized, placebo-controlled trial of solriamfetol to treat binge eating disorder.
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DOI: 10.1016/j.cct.2021.106587
Abstract: INTRODUCTION Binge eating disorder (BED) is an important public health problem associated with severe psychosocial and medical consequences for which treatment options are limited. The objective of this study is to evaluate the efficacy and… read more here.
Keywords: eating disorder; binge eating; trial; study ... See more keywords
Solriamfetol for the treatment of excessive daytime sleepiness associated with narcolepsy
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2019.1632705
Abstract: ABSTRACT Introduction: Narcolepsy is a chronic disabling condition, excessive daytime somnolence is the main symptoms of it. There is currently no cure for narcolepsy, and hence there is a great need for new treatment options.… read more here.
Keywords: excessive daytime; treatment; sleepiness; dopamine norepinephrine ... See more keywords
0559 Solriamfetol Demonstrates Durable Cognitive Improvement in Adults with Obstructive Sleep Apnea and Excessive Daytime Sleepiness
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DOI: 10.1093/sleep/zsad077.0559
Abstract: Obstructive sleep apnea (OSA) is a common disorder characterized by repeated intermittent airway collapse—often a hypoxic event—resulting in disrupted sleep and excessive daytime sleepiness (EDS). Positive Airway Pressure (PAP) therapy reduces hypoxic events and mitigates… read more here.
Keywords: solriamfetol; daytime sleepiness; sleep apnea; obstructive sleep ... See more keywords
Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3). A Randomized Controlled Trial.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.201806-1100oc
Abstract: Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the… read more here.
Keywords: sleep apnea; apnea; excessive sleepiness; solriamfetol ... See more keywords
Solriamfetol for Excessive Sleepiness in Narcolepsy and Obstructive Sleep Apnea
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DOI: 10.1177/1060028020915537
Abstract: Objective: The purpose of this article is to review the available clinical trial data that led to the Food and Drug Administration (FDA) approval of solriamfetol as well as its role in clinical practice. Data… read more here.
Keywords: narcolepsy obstructive; excessive sleepiness; obstructive sleep; sleep apnea ... See more keywords