Tailoring Deep Eutectic Solvents to Provoke Solubility and Bioavailability of Naringin: Implications of a Computational Approach
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DOI: 10.1021/acsomega.2c08079
Abstract: Recently, the applications of deep eutectic solvents (DESs) as green and sustainable solvents for the solubilization of functional foods and phytophenols have dramatically risen concerning global issues on the utilization of organic solvents. Nevertheless, developing… read more here.
Keywords: deep eutectic; solubility; bioavailability naringin; bioavailability ... See more keywords
Promising Nanocarriers to Enhance Solubility and Bioavailability of Cannabidiol for a Plethora of Therapeutic Opportunities
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DOI: 10.3390/molecules27186070
Abstract: In recent years, the interest in cannabidiol (CBD) has increased because of the lack of psychoactive properties. However, CBD has low solubility and bioavailability, variable pharmacokinetics profiles, poor stability, and a pronounced presystemic metabolism. CBD… read more here.
Keywords: solubility; cannabidiol; solubility bioavailability; therapeutic opportunities ... See more keywords
Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
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DOI: 10.3390/molecules27227740
Abstract: Cantharidin (CTD) is the main active ingredient isolated from Mylabris, and norcantharidin (NCTD) is a demethylated derivative of CTD, which has similar antitumor activity to CTD and lower toxicity than CTD. However, the clinical use… read more here.
Keywords: strategies solubility; bioavailability; toxicity; solubility bioavailability ... See more keywords
Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS)
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DOI: 10.3390/pharmaceutics14030482
Abstract: The purpose of the study was to develop an SNEDDS to improve the solubility and bioavailability of pitavastatin. The solubility of pitavastatin in different oils, surfactants, and co-surfactants was determined and a pseudo-ternary phase diagram… read more here.
Keywords: bioavailability pitavastatin; solubility; solubility bioavailability; pitavastatin ... See more keywords