Saturation Solubility and Dissolution Property Improvement of Albendazole by Salt Formation Approach
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DOI: 10.1007/s12247-021-09588-9
Abstract: Albendazole belongs to BCS-II category whose systemic and local anthelmintic effectiveness is restricted due to its low water solubility–related dissolution properties. The present investigation was aimed to prepare salts of albendazole using various weak organic… read more here.
Keywords: salt formation; saturation solubility; solubility dissolution; acid ... See more keywords
Equilibrium Solubility and Dissolution Property Analysis of 2-Nitrophenylacetic Acid in 13 Pure Solvents at Elevated Temperatures
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DOI: 10.1021/acs.jced.0c00543
Abstract: This work was devoted to the equilibrium solubility of 2-nitrophenylacetic acid in 13 neat solvents ethylene glycol (EG), methanol, ethanol, acetonitrile, n-propanol, isopropanol, water, n-butanol, N,N-dimethylformamide (DMF), isobutanol, cyclohexane, ethyl acetate, and 1,4-dioxane ranging from… read more here.
Keywords: solubility dissolution; equilibrium solubility; solubility; nitrophenylacetic acid ... See more keywords
Rivaroxaban Eutectics with Improved Solubility, Dissolution Rate, Bioavailability and Stability
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DOI: 10.1039/d3ce00261f
Abstract: Rivaroxaban (RXB) is a direct factor Xa inhibitor used for the treatment of deep vein thrombosis (DVT, a blood clot in the leg), pulmonary embolisms (PE, a blood clot in... read more here.
Keywords: dissolution rate; rate bioavailability; solubility dissolution; improved solubility ... See more keywords
Development of eplerenone nano sono-crystals using factorial design: enhanced solubility and dissolution rate via anti solvent crystallization technique
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DOI: 10.1080/03639045.2022.2160985
Abstract: Abstract Objective The purpose of this work was to improve EP solubility by using a sono-crystalization approach to reduce particle size and hence, increase the dissolution rate. Significance Eplerenone (EP) is an antagonist of the… read more here.
Keywords: solubility dissolution; rate; eplerenone; dissolution rate ... See more keywords
Robust Wet Milling Technique for Producing Micronized Ibuprofen Particles with Improved Solubility and Dissolution
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DOI: 10.1208/s12249-022-02480-w
Abstract: This study investigated a systematic approach for producing ibuprofen (IBF) particles with leucine by wet milling. Using a high shear homogenizer, the particles size of the IBF was reduced. Prepared IBF microparticles were freeze-dried and… read more here.
Keywords: solubility dissolution; solubility; wet milling; ibf ... See more keywords
Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and Dissolution Enhancer in Solid Dispersion
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DOI: 10.3390/ph15070869
Abstract: Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. Ocimum basilicum (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug, aceclofenac, in… read more here.
Keywords: solid dispersions; polymer; solubility dissolution; solubility ... See more keywords
Fabrication of Capsaicin Loaded Nanocrystals: Physical Characterizations and In Vivo Evaluation
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DOI: 10.3390/pharmaceutics13060841
Abstract: Nano-crystallization is a new emerging strategy to promote the saturation solubility, dissolution rate and subsequent bioavailability of Biopharmaceutical Class II drugs. Capsaicin belongs to BCS class-II drugs having low water solubility and dissolution rate. Nano-crystals… read more here.
Keywords: drug; solubility dissolution; capsaicin; surface ... See more keywords
How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions: Optimization and In-Vitro Characterization
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DOI: 10.3390/pharmaceutics14112264
Abstract: The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon® VA 64, Kolliphor® P… read more here.
Keywords: solid dispersion; solubility dissolution; solubility; ternary solid ... See more keywords
The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character
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DOI: 10.3390/pharmaceutics15010278
Abstract: Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly… read more here.
Keywords: particle size; dissolution; solubility; solubility dissolution ... See more keywords
Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation
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DOI: 10.3390/pharmaceutics15020363
Abstract: Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited… read more here.
Keywords: dissolution rate; dissolution; solubility dissolution; bioavailability ... See more keywords
Synthesis, Characterization and Performance Evaluation of Aceclofenac-Urea Cocrystals
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DOI: 10.36468/pharmaceutical-sciences.717
Abstract: Aceclofenac is one of the commonly used Nonsteroidal anti-inflammatory drugs representing the variety of therapeutic applications including management of pain, inflammation, rheumatoid arthritis, and osteoarthritis, etc. But very low solubility and dissolution rate of aceclofenac… read more here.
Keywords: dissolution rate; solubility dissolution; synthesized cocrystals; aceclofenac urea ... See more keywords