Solubility vs Dissolution in Physiological Bicarbonate Buffer
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DOI: 10.1007/s11095-024-03702-5
Abstract: Phosphate buffer is often used as a replacement for the physiological bicarbonate buffer in pharmaceutical dissolution testing, although there are some discrepancies in their properties making it complicated to extrapolate dissolution results in phosphate to… read more here.
Keywords: bicarbonate; bicarbonate buffer; solubility dissolution; dissolution ... See more keywords
Saturation Solubility and Dissolution Property Improvement of Albendazole by Salt Formation Approach
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DOI: 10.1007/s12247-021-09588-9
Abstract: Albendazole belongs to BCS-II category whose systemic and local anthelmintic effectiveness is restricted due to its low water solubility–related dissolution properties. The present investigation was aimed to prepare salts of albendazole using various weak organic… read more here.
Keywords: salt formation; saturation solubility; solubility dissolution; acid ... See more keywords
Equilibrium Solubility and Dissolution Property Analysis of 2-Nitrophenylacetic Acid in 13 Pure Solvents at Elevated Temperatures
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DOI: 10.1021/acs.jced.0c00543
Abstract: This work was devoted to the equilibrium solubility of 2-nitrophenylacetic acid in 13 neat solvents ethylene glycol (EG), methanol, ethanol, acetonitrile, n-propanol, isopropanol, water, n-butanol, N,N-dimethylformamide (DMF), isobutanol, cyclohexane, ethyl acetate, and 1,4-dioxane ranging from… read more here.
Keywords: solubility dissolution; equilibrium solubility; solubility; nitrophenylacetic acid ... See more keywords
Enhancing solubility and dissolution of felodipine using self-nanoemulsifying drug systems through in vitro evaluation
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DOI: 10.1038/s41598-025-90962-9
Abstract: The main objective of the present study was to improve the solubility and dissolution rate of felodipine (FLD), a drug that does not dissolve well in water, using a self-nanoemulsifying drug delivery system (SNEDDS). Many… read more here.
Keywords: solubility dissolution; self nanoemulsifying; using self; dissolution ... See more keywords
Rivaroxaban Eutectics with Improved Solubility, Dissolution Rate, Bioavailability and Stability
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DOI: 10.1039/d3ce00261f
Abstract: Rivaroxaban (RXB) is a direct factor Xa inhibitor used for the treatment of deep vein thrombosis (DVT, a blood clot in the leg), pulmonary embolisms (PE, a blood clot in... read more here.
Keywords: dissolution rate; rate bioavailability; solubility dissolution; improved solubility ... See more keywords
Development of eplerenone nano sono-crystals using factorial design: enhanced solubility and dissolution rate via anti solvent crystallization technique
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DOI: 10.1080/03639045.2022.2160985
Abstract: Abstract Objective The purpose of this work was to improve EP solubility by using a sono-crystalization approach to reduce particle size and hence, increase the dissolution rate. Significance Eplerenone (EP) is an antagonist of the… read more here.
Keywords: solubility dissolution; rate; eplerenone; dissolution rate ... See more keywords
Meloxicam-amino acids salts/ion pair complexes with advanced solubility, dissolution, and gastric safety
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DOI: 10.1080/10837450.2024.2417766
Abstract: Abstract Amino acids have attracted attention as a potential functional excipient for optimizing biopharmaceutics characteristics of poorly soluble drugs. The amino acids are a diverse class with many functional groups, natural compounds, biocompatible, and low-molecular-weight… read more here.
Keywords: amino acids; solubility dissolution; meloxicam; solubility ... See more keywords
Robust Wet Milling Technique for Producing Micronized Ibuprofen Particles with Improved Solubility and Dissolution
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DOI: 10.1208/s12249-022-02480-w
Abstract: This study investigated a systematic approach for producing ibuprofen (IBF) particles with leucine by wet milling. Using a high shear homogenizer, the particles size of the IBF was reduced. Prepared IBF microparticles were freeze-dried and… read more here.
Keywords: solubility dissolution; solubility; wet milling; ibf ... See more keywords
The influence of natural polymers on loratadine's solubility and dissolution profiles
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DOI: 10.25122/jml-2023-0529
Abstract: Second-generation tricyclic H1 antihistamine loratadine (LTD) has a high permeability, low water solubility, and an oral absorption rate dependent on the rate at which it dissolves in the gastrointestinal tract. One approach suggested for improving… read more here.
Keywords: natural polymers; solubility dissolution; dissolution; dissolution rate ... See more keywords
Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and Dissolution Enhancer in Solid Dispersion
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DOI: 10.3390/ph15070869
Abstract: Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. Ocimum basilicum (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug, aceclofenac, in… read more here.
Keywords: solid dispersions; polymer; solubility dissolution; solubility ... See more keywords
Evaluation of Solubility, Dissolution Rate, and Oral Bioavailability of β-Cyclodextrin and Hydroxypropyl β-Cyclodextrin as Inclusion Complexes of the Tyrosine Kinase Inhibitor, Alectinib
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DOI: 10.3390/ph17060737
Abstract: This study aims to improve the solubility and dissolution rate of alectinib (ALB), a tyrosine kinase inhibitor commonly used for treating non-small-cell carcinoma (NSCLC). Given ALB’s low solubility and bioavailability, complexation with β-cyclodextrin (βCD) and… read more here.
Keywords: dissolution rate; solubility dissolution; dissolution; cyclodextrin ... See more keywords