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Published in 2021 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-021-09588-9
Abstract: Albendazole belongs to BCS-II category whose systemic and local anthelmintic effectiveness is restricted due to its low water solubility–related dissolution properties. The present investigation was aimed to prepare salts of albendazole using various weak organic…
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Keywords:
salt formation;
saturation solubility;
solubility dissolution;
acid ... See more keywords
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Published in 2020 at "Journal of Chemical & Engineering Data"
DOI: 10.1021/acs.jced.0c00543
Abstract: This work was devoted to the equilibrium solubility of 2-nitrophenylacetic acid in 13 neat solvents ethylene glycol (EG), methanol, ethanol, acetonitrile, n-propanol, isopropanol, water, n-butanol, N,N-dimethylformamide (DMF), isobutanol, cyclohexane, ethyl acetate, and 1,4-dioxane ranging from…
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Keywords:
solubility dissolution;
equilibrium solubility;
solubility;
nitrophenylacetic acid ... See more keywords
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2
Published in 2023 at "CrystEngComm"
DOI: 10.1039/d3ce00261f
Abstract: Rivaroxaban (RXB) is a direct factor Xa inhibitor used for the treatment of deep vein thrombosis (DVT, a blood clot in the leg), pulmonary embolisms (PE, a blood clot in...
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Keywords:
dissolution rate;
rate bioavailability;
solubility dissolution;
improved solubility ... See more keywords
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Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2160985
Abstract: Abstract Objective The purpose of this work was to improve EP solubility by using a sono-crystalization approach to reduce particle size and hence, increase the dissolution rate. Significance Eplerenone (EP) is an antagonist of the…
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Keywords:
solubility dissolution;
rate;
eplerenone;
dissolution rate ... See more keywords
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Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02480-w
Abstract: This study investigated a systematic approach for producing ibuprofen (IBF) particles with leucine by wet milling. Using a high shear homogenizer, the particles size of the IBF was reduced. Prepared IBF microparticles were freeze-dried and…
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Keywords:
solubility dissolution;
solubility;
wet milling;
ibf ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070869
Abstract: Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. Ocimum basilicum (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug, aceclofenac, in…
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Keywords:
solid dispersions;
polymer;
solubility dissolution;
solubility ... See more keywords
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Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13060841
Abstract: Nano-crystallization is a new emerging strategy to promote the saturation solubility, dissolution rate and subsequent bioavailability of Biopharmaceutical Class II drugs. Capsaicin belongs to BCS class-II drugs having low water solubility and dissolution rate. Nano-crystals…
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Keywords:
drug;
solubility dissolution;
capsaicin;
surface ... See more keywords
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Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112264
Abstract: The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon® VA 64, Kolliphor® P…
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Keywords:
solid dispersion;
solubility dissolution;
solubility;
ternary solid ... See more keywords
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2
Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010278
Abstract: Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly…
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Keywords:
particle size;
dissolution;
solubility;
solubility dissolution ... See more keywords
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Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020363
Abstract: Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited…
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Keywords:
dissolution rate;
dissolution;
solubility dissolution;
bioavailability ... See more keywords
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Published in 2020 at "Indian Journal of Pharmaceutical Sciences"
DOI: 10.36468/pharmaceutical-sciences.717
Abstract: Aceclofenac is one of the commonly used Nonsteroidal anti-inflammatory drugs representing the variety of therapeutic applications including management of pain, inflammation, rheumatoid arthritis, and osteoarthritis, etc. But very low solubility and dissolution rate of aceclofenac…
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Keywords:
dissolution rate;
solubility dissolution;
synthesized cocrystals;
aceclofenac urea ... See more keywords