Cannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119812
Abstract: Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on… read more here.
Keywords: cbd; aqueous solubility; solubility enhancement; solubility ... See more keywords
Solubility enhancement of simvastatin and atorvastatin by arginine: A solvodynamics study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.05.003
Abstract: Abstract Arginine (ARG) aided solubility enhancement of statin-based model drugs such as simvastatin (SMV) and atorvastatin (ATV) has been reported. Herein, both SMV and ATV are considered as a solute, whereas ARG the cosolute. The… read more here.
Keywords: atv; arg; arginine; solubility enhancement ... See more keywords
Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.08.017
Abstract: It is for the pharmaceutical sciences of vital importance to understand how drugs are solubilized in biorelevant media. However, the complexity of fasted state simulated intestinal fluid (FaSSIF) has so far hampered adequate solubility modeling.… read more here.
Keywords: biorelevant drug; energy relationship; drug; solubility enhancement ... See more keywords
Solubility Enhancement of Vitamins in Water in the Presence of Covitamins: Measurements and ePC-SAFT Predictions
Sign Up to like & getrecommendations! Published in 2019 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.9b04302
Abstract: Scarce knowledge on the behavior of vitamins in aqueous solutions in the presence of additives is often a limiting factor for industrial applications such as process design and optimization. Knowing the pH-solubility profiles of vitamins… read more here.
Keywords: enhancement vitamins; presence; solubility enhancement; solubility ... See more keywords
Dual Functionality of Bile Acid: Physical Stabilization of Drugs in the Amorphous Form and Solubility Enhancement in Solution.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00294
Abstract: Drugs containing an amino aromatic nitrogen moiety were stabilized in the amorphous form by the surfactant cholic acid (CA). Coamorphous systems of lamotrigine (LAM), pyrimethamine (PYR), and trimethoprim (TRI) were each prepared with CA. Drug-CA… read more here.
Keywords: solubility; coamorphous systems; amorphous form; drug ... See more keywords
Unexpected Solubility Enhancement of Drug Bases in the Presence of a Dimethylaminoethyl Methacrylate Copolymer.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00804
Abstract: The methacrylate copolymer Eudragit EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type of interaction could also… read more here.
Keywords: presence; methacrylate copolymer; drug; solubility enhancement ... See more keywords
Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01694-0
Abstract: Current study is focused to enhance the solubility of poorly soluble drug olanzapine (OLZ) by nanogels drug delivery system, as improved solubility is one of the most important applications of nanosystems. Poor solubility is a… read more here.
Keywords: cross linked; acrylamido methylpropane; solubility enhancement; poloxamer 407 ... See more keywords
Choline-Amino Acid-Derived Bio-ionic Liquids for Solubility Enhancement of Zafirlukast
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02296-8
Abstract: This study investigated the application of bio-ionic liquids (ILs) prepared from choline as cation and amino acid as anion for solubility enhancement of poorly water-soluble drug, Zafirlukast (ZFL). Herein, the solubility of ZFL in water… read more here.
Keywords: zfl; solubility; water; ionic liquids ... See more keywords
Synthesis of Quarternized Chitosans and Their Potential Applications in the Solubility Enhancement of Indomethacin by Solid Dispersion
Sign Up to like & getrecommendations! Published in 2024 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-024-02893-9
Abstract: This study was designed to synthesize quarternized chitosans (Q-CS) and explore their potential application in aqueous solubility enhancement of indomethacin (IND), a BCS class-II drug. Three different Q-CS; N,N,N-trimethyl chitosan chloride (TMC), N-(4-N‘-methylpyridinylmethyl) chitosan chloride… read more here.
Keywords: quarternized chitosans; enhancement indomethacin; solid dispersion; solubility enhancement ... See more keywords
Solubility enhancement and antioxidation maintenance of CBD encapsulated in the P407-RUB nano-micelle system.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug delivery"
DOI: 10.2174/1567201820666230330090025
Abstract: AIM The aim of this study is to improve the water solubility and stability of cannabidiol (CBD) utilizing micelle technology. MATERIALS AND METHODS Mixing of rubusoside (RUB) with Poloxamer 407 (P407) was explored as the… read more here.
Keywords: p407 rub; solubility; micelle; cbd ... See more keywords
Benchmarking the Solubility Enhancement and Storage Stability of Amorphous Drug–Polyelectrolyte Nanoplex against Co-Amorphous Formulation of the Same Drug
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050979
Abstract: Amorphization, typically in the form of amorphous solid dispersion (ASD), represents a well-established solubility enhancement strategy for poorly soluble drugs. Recently, two amorphous drug formulations, i.e., the amorphous drug–polyelectrolyte nanoparticle complex (nanoplex) and co-amorphous system,… read more here.
Keywords: nanoplex amorphous; drug polyelectrolyte; amorphous drug; stability ... See more keywords