The comparative study of cocrystal/salt in simultaneously improving solubility and permeability of acetazolamide
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.01.090
Abstract: Abstract With the purpose of improving solubility and permeability of acetazolamide (ACZ), two new solid forms including one salt with piperazine (PPZ), and one cocrystal with theophylline (THP), namely, ACZ-PPZ-H2O (1) and ACZ-THP (2), were… read more here.
Keywords: salt; solubility; permeability; permeability acetazolamide ... See more keywords
Striking the Optimal Solubility-Permeability Balance in Oral Formulation Development for Lipophilic Drugs: Maximizing Carbamazepine Blood Levels.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.6b00967
Abstract: The purpose of this research was to investigate the performance of cosolvent based solubility-enabling formulations in oral delivery of lipophilic drugs, accounting for the gastrointestinal tract (GIT) luminal solubilization processes, the solubility-permeability interplay, and the… read more here.
Keywords: lipophilic drugs; formulation; peg 400; solubility permeability ... See more keywords
Rebamipide nanocrystal with improved physicomechanical properties and its assessment through bio-mimicking 3D intestinal permeability model.
Sign Up to like & getrecommendations! Published in 2024 at "Nanoscale"
DOI: 10.1039/d4nr03137g
Abstract: This study investigated the formulation and characterization of rebamipide nanocrystals (REB-NCs) to enhance the solubility and permeability of rebamipide, an anti-ulcer medication known for its low aqueous solubility and permeability, classified as BCS class IV.… read more here.
Keywords: permeability; solubility permeability; reb ncs; rebamipide ... See more keywords
Nanoemulsion for improving solubility and permeability of Vitex agnus-castus extract: formulation and in vitro evaluation using PAMPA and Caco-2 approaches
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2016.1256002
Abstract: Abstract The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion… read more here.
Keywords: formulation; extract formulation; vitex agnus; solubility ... See more keywords
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
Sign Up to like & getrecommendations! Published in 2024 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adm8631
Abstract: Cryptosporidiosis is a diarrheal disease caused by infection with Cryptosporidium spp. parasites and is a leading cause of death in malnourished children worldwide. The only approved treatment, nitazoxanide, has limited efficacy in this at-risk patient… read more here.
Keywords: synthetase inhibitors; solubility permeability; trna synthetase; efficacy ... See more keywords
Dose-Dependent Solubility–Permeability Interplay for Poorly Soluble Drugs under Non-Sink Conditions
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13030323
Abstract: We investigated the solubility–permeability interplay using a solubilizer additive under non-sink conditions. Sodium lauryl sulfate (SLS) was used as a solubilizer additive. The solubility and permeability of two poorly soluble drugs at various doses, with… read more here.
Keywords: amount; permeability; solubility permeability; solubility ... See more keywords
Revisiting the Solubility–Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020422
Abstract: This study describes the influence of pluronic F-127 (F-127) and ethanol (EtOH) on the solubility of umifenovir (UMF) in buffer solutions of pH 2.0 and pH 7.4, and its permeability through cellulose membranes. A 44.4-fold… read more here.
Keywords: revisiting solubility; 127 micelles; permeability relationship; solubility ... See more keywords
Formulation and characterization of Triamcinolone acetonide loaded transferosomal vesicles: An attempt for solubility and permeability enhancement for its vaginal delivery
Sign Up to like & getrecommendations! Published in 2024 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2024.00515
Abstract: The objective of the present study is to develop Triamcinolone acetonide containing transferosomal vesicles in the vagina for the treatment of vaginal inflammation in candidiasis conditions, being a BCS class-IV drug, having low solubility and… read more here.
Keywords: acetonide loaded; triamcinolone acetonide; solubility permeability; permeability ... See more keywords