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   Articles with "solubility permeability" as a keyword



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The comparative study of cocrystal/salt in simultaneously improving solubility and permeability of acetazolamide

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recommendations! Published in 2019 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2019.01.090

Abstract: Abstract With the purpose of improving solubility and permeability of acetazolamide (ACZ), two new solid forms including one salt with piperazine (PPZ), and one cocrystal with theophylline (THP), namely, ACZ-PPZ-H2O (1) and ACZ-THP (2), were… read more here.

Keywords: salt; solubility; permeability; permeability acetazolamide ... See more keywords
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Striking the Optimal Solubility-Permeability Balance in Oral Formulation Development for Lipophilic Drugs: Maximizing Carbamazepine Blood Levels.

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recommendations! Published in 2017 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.6b00967

Abstract: The purpose of this research was to investigate the performance of cosolvent based solubility-enabling formulations in oral delivery of lipophilic drugs, accounting for the gastrointestinal tract (GIT) luminal solubilization processes, the solubility-permeability interplay, and the… read more here.

Keywords: lipophilic drugs; formulation; peg 400; solubility permeability ... See more keywords
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Nanoemulsion for improving solubility and permeability of Vitex agnus-castus extract: formulation and in vitro evaluation using PAMPA and Caco-2 approaches

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recommendations! Published in 2017 at "Drug Delivery"

DOI: 10.1080/10717544.2016.1256002

Abstract: Abstract The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion… read more here.

Keywords: formulation; extract formulation; vitex agnus; solubility ... See more keywords
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Dose-Dependent Solubility–Permeability Interplay for Poorly Soluble Drugs under Non-Sink Conditions

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recommendations! Published in 2021 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics13030323

Abstract: We investigated the solubility–permeability interplay using a solubilizer additive under non-sink conditions. Sodium lauryl sulfate (SLS) was used as a solubilizer additive. The solubility and permeability of two poorly soluble drugs at various doses, with… read more here.

Keywords: amount; permeability; solubility permeability; solubility ... See more keywords
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Revisiting the Solubility–Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent

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recommendations! Published in 2023 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics15020422

Abstract: This study describes the influence of pluronic F-127 (F-127) and ethanol (EtOH) on the solubility of umifenovir (UMF) in buffer solutions of pH 2.0 and pH 7.4, and its permeability through cellulose membranes. A 44.4-fold… read more here.

Keywords: revisiting solubility; 127 micelles; permeability relationship; solubility ... See more keywords