Enhanced water solubility, stability, and in vitro antitumor activity of ferulic acid by chemical conjugation with amino-β-cyclodextrins
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Science"
DOI: 10.1007/s10853-020-04621-7
Abstract: To improve the water solubility, stability and bioactivity of ferulic acid (FA), a series of conjugates (FA-NH-CD, FA-EDA-CD, and FA-HDA-CD) were synthesized by bonding FA with different amino-β-cyclodextrins (amino-β-CD, ACDs) through amidation reactions. The structures… read more here.
Keywords: water solubility; solubility; ferulic acid; stability ... See more keywords
Effect of β-cyclodextrin and different surfactants on solubility, stability, and permeability of hydrochlorothiazide
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.12.006
Abstract: Abstract Physicochemical properties play a pivotal role in the absorption mechanism of orally administered drugs. Hydrochlorothiazide (HZT), a class IV drug inherently lacks the required solubility and permeability. In addition, the drug tends to degrade… read more here.
Keywords: permeability; solubility; hzt; stability permeability ... See more keywords
Improving shikonin solubility and stability by encapsulation in natural surfactant-coated shikonin nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of food science"
DOI: 10.1111/1750-3841.16445
Abstract: It is significant to develop a colloidal delivery system to improve the water solubility, stability, and bioavailability of shikonin, which is a hydrophobic plant polyphenol with a variety of physiological activities. In this study, three… read more here.
Keywords: shikonin nanoparticles; coated shikonin; saponin sophorolipid; solubility stability ... See more keywords
Enhanced Solubility and Stability of Aripiprazole in Binary and Ternary Inclusion Complexes Using Hydroxy Propyl Beta Cyclodextrin (HPβCD) and L-Arginine
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DOI: 10.3390/molecules28093860
Abstract: The low water solubility of an active pharmaceutical ingredient (aripiprazole) is one of the most critical challenges in pharmaceutical research and development. This antipsychotic drug has an inadequate therapeutic impact because of its minimal and… read more here.
Keywords: solubility; inclusion complexes; solubility stability; stability ... See more keywords
Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010232
Abstract: The biopharmaceutical classification system groups low-solubility drugs into two groups: II and IV, with high and low permeability, respectively. Most of the new drugs developed for common pathologies present solubility issues. This is the case… read more here.
Keywords: lurasidone hydrochloride; hydroxypropyl cyclodextrin; solubility; solubility stability ... See more keywords