Arginine Complexes with Simvastatin: Apparent Solubility, In Vitro Dissolution and Solid State Characterization.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug delivery"
DOI: 10.2174/1567201814666170320144259
Abstract: BACKGROUND Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, statin exhibit low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. This paper describes a de novo approach… read more here.
Keywords: dissolution solid; vitro dissolution; solubility; solubility vitro ... See more keywords
Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15080998
Abstract: An antileishmanial structure–activity relationship (SAR) study focused on positions 2 and 8 of the imidazo[1,2-a]pyridine ring was conducted through the synthesis of 22 new derivatives. After being screened on the promatigote and axenic amastigote stages… read more here.
Keywords: solubility vitro; pharmacokinetic properties; vitro pharmacokinetic; aqueous solubility ... See more keywords