Solubilization and renaturation of biologically active human bone morphogenetic protein-4 from inclusion bodies
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DOI: 10.1016/j.btre.2018.e00249
Abstract: Highlights • Biologically active rhBMP-4 was produced in a prokaryotic host as inclusion bodies.• Different refolding recipes were tested for optimal dimerization yield.• One-step purification of dimer with cation-exchange membrane chromatography.• The product induces trophoblast… read more here.
Keywords: inclusion bodies; renaturation biologically; biologically active; active human ... See more keywords