Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13754
Abstract: Recurrence rates of both lentigo maligna (LM) and lentigo maligna melanoma (LMM) following conventional surgery are usually relatively high. We aimed to assess the frequencies of melanocytes in tumour‐free margins around LM/LMM using soluble adenylyl… read more here.
Keywords: lentigo maligna; around lmm; adenylyl cyclase; soluble adenylyl ... See more keywords
Bicarbonate‐sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13090
Abstract: The enzyme soluble adenylyl cyclase (sAC) is directly stimulated by bicarbonate (HCO3−) to produce the signaling molecule cyclic adenosine monophosphate (cAMP). Because sAC and sAC‐related enzymes are found throughout phyla from cyanobacteria to mammals and… read more here.
Keywords: adenylyl cyclase; soluble adenylyl; sac; shark ... See more keywords
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.953903
Abstract: In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th… read more here.
Keywords: cyclase; contraception; adenylyl cyclase; strategies safely ... See more keywords
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1013845
Abstract: In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3 −)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely essential in sperm for reproduction.… read more here.
Keywords: binding kinetics; sac; cyclase sac; adenylyl cyclase ... See more keywords