Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound.
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DOI: 10.1016/j.ejmech.2021.113544
Abstract: 10-Hydroxyevodiamine is a multitargeting antitumor lead compound with excellent in vitro activity. However, its in vivo antitumor potency is rather limited, which has hampered its further clinical development. To overcome this obstacle, a series of novel water-soluble… read more here.
Keywords: soluble derivatives; lead compound; water soluble; antitumor lead ... See more keywords