Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1859
Abstract: Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor… read more here.
Keywords: poorly soluble; technology; delivery poorly; soluble drugs ... See more keywords
Montmorillonite-lipid hybrid carriers for ionizable and neutral poorly water-soluble drugs: Formulation, characterization and in vitro lipolysis studies.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.063
Abstract: Lipid-based formulations (LBFs) are a popular strategy for enhancing the gastrointestinal solubilization and absorption of poorly water-soluble drugs. In light of this, montmorillonite-lipid hybrid (MLH) particles, composed of medium-chain triglycerides, lecithin and montmorillonite clay platelets,… read more here.
Keywords: soluble drugs; water soluble; lipid hybrid; poorly water ... See more keywords
Spray drying of poorly soluble drugs from aqueous arginine solution.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.015
Abstract: Co-amorphous drug-amino acid mixtures have shown potential for improving the solid-state stability and dissolution behavior of amorphous drugs. In previous studies, however these mixtures have been produced mainly with small-scale preparation methods, or with methods… read more here.
Keywords: poorly soluble; spray drying; drying poorly; soluble drugs ... See more keywords
Mechanistic understanding of the phase behavior of supersaturated solutions of poorly water‐soluble drugs
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.03.038
Abstract: &NA; Amorphous solid dispersions (ASDs) are a promising formulation strategy to increase both the apparent aqueous solubility and bioavailability of poorly water‐soluble drugs. Upon dissolution under nonsink conditions, ASDs can generate highly supersaturated drug solutions… read more here.
Keywords: phase; water; soluble drugs; water soluble ... See more keywords
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2023.2150758
Abstract: ABSTRACT Introduction Self-emulsifying drug delivery systems (SEDDS) are formulations consisting of oil phase, emulsifiers, and co-emulsifiers, which can be spontaneously emulsified in the body to form O/W microemulsion. Traditionally, SEDDS are used commercially for the… read more here.
Keywords: drug delivery; delivery; water soluble; soluble drugs ... See more keywords
Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav9784
Abstract: Computer-assisted strategy for drug delivery leads to discovery of polymeric micelle formulations for poorly soluble drugs. Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable… read more here.
Keywords: poorly soluble; discovery polymeric; soluble drugs; drug ... See more keywords
Cyclodextrin Complex Formation with Water-Soluble Drugs: Conclusions from Isothermal Titration Calorimetry and Molecular Modeling
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-02040-8
Abstract: Cyclodextrin (CD) complexes are frequently used for enhancing the solubility or absorption of poorly water-soluble drugs. On the contrary, little is known about their complex formation with water-soluble drugs. Here, we have studied the interaction… read more here.
Keywords: soluble drugs; formation water; water soluble; complex formation ... See more keywords
Nanoprecipitation for Poorly Water-Soluble Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug metabolism"
DOI: 10.2174/1389200218666171004112122
Abstract: BACKGROUND More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects. METHODS Nanoprecipitation presents some advantages… read more here.
Keywords: soluble drugs; water soluble; drug; poorly water ... See more keywords
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092055
Abstract: The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with low solubility convey a… read more here.
Keywords: solubility; bioavailability; soluble drugs; drug ... See more keywords
Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24193471
Abstract: The low and variable oral bioavailability of poorly water soluble drugs remains a major concern for the pharmaceutical industry. Spray congealing is an emerging technology for the production of solid dispersion to enhance the bioavailability… read more here.
Keywords: oral bioavailability; soluble drugs; bioavailability; bioavailability poorly ... See more keywords
Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Nanomaterials"
DOI: 10.3390/nano9081148
Abstract: The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential… read more here.
Keywords: poorly soluble; polymer nanoparticle; soluble drugs; hybrid systems ... See more keywords