Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200137
Abstract: Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation‐related pathologies in the context of cardiovascular, central nervous system and metabolic diseases. In our search for novel sEH inhibitors, we designed and… read more here.
Keywords: seh; seh inhibitors; soluble epoxide; epoxide hydrolase ... See more keywords
Soluble epoxide hydrolase inhibitory activity of phenolic glycosides from Polygala tenuifolia and in silico approach
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DOI: 10.1007/s00044-017-2096-2
Abstract: The goal of this study was to identify soluble epoxide hydrolase (sEH) inhibitors from plants. Our efforts led to the isolation of nine phenolic glycosides 1–9 from the roots of Polygala tenuifolia Willd. The structures… read more here.
Keywords: soluble epoxide; polygala tenuifolia; epoxide hydrolase; phenolic glycosides ... See more keywords
Testing Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage: Rare Diseases, Orphan Drugs, the Conundrum
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DOI: 10.1007/s12028-021-01410-1
Abstract: The Orphan Drug Act (1988) defines a “rare disease” as a disease or condition that affects less than 200,000 people in the United States. With an incidence of 7.9 (95% confidence interval 6.9–9.0) per 100,000… read more here.
Keywords: study; medicine; epoxide hydrolase; aneurysmal subarachnoid ... See more keywords
Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2016.10.017
Abstract: Soluble epoxide hydrolase (sEH) is an important therapeutic target of many diseases, such as chronic obstructive pulmonary disease (COPD) and diabetic neuropathic pain. It acts by hydrolyzing and thus regulating specific bioactive long chain polyunsaturated… read more here.
Keywords: soluble epoxide; orientation; epoxide hydrolase; probing orientation ... See more keywords
Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109571
Abstract: Soluble epoxide hydrolase (sEH) is a potential drug target to treat inflammation and neurodegenerative diseases. In this study, we found that the extract of Inula britanica exhibited significantly inhibitory effects against sEH, therefore, we investigated… read more here.
Keywords: soluble epoxide; epoxide hydrolase; inula britanica; inhibition kinetics ... See more keywords
Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress.
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DOI: 10.1016/j.celrep.2019.11.006
Abstract: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in depression. Here,… read more here.
Keywords: chronic stress; soluble epoxide; epoxide hydrolase; liver soluble ... See more keywords
Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
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DOI: 10.1016/j.chest.2016.10.058
Abstract: BACKGROUND: Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium‐derived epoxyeicosatrienoic acid (EET)‐mediated endothelial function is impaired in patients with COPD and… read more here.
Keywords: soluble epoxide; patients copd; novel soluble; epoxide hydrolase ... See more keywords
In silico investigation of cycloartane triterpene derivatives from Cimicifuga dahurica (Turcz.) Maxim. roots for the development of potent soluble epoxide hydrolase inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.02.023
Abstract: In our search for natural soluble epoxide hydrolase (sEH) inhibitors from plants, we found that an ethanolic extract of the roots of Cimicifuga dahurica (Turcz.) Maxim. significantly inhibits sEH in vitro. A phytochemical study on… read more here.
Keywords: soluble epoxide; epoxide hydrolase; cycloartane; cimicifuga dahurica ... See more keywords
In vitro and in silico investigation of anthocyanin derivatives as soluble epoxide hydrolase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.02.061
Abstract: Anthocyanin derivatives are well-known secondary constituents contained in fruits. The inhibitory activity of anthocyanin derivatives toward soluble epoxide hydrolase (sEH) was tested for potential applications in the treatment of cardiovascular diseases. Anthocyanin derivatives 1-5 showed… read more here.
Keywords: soluble epoxide; anthocyanin derivatives; epoxide hydrolase; anthocyanin ... See more keywords
Natural soluble epoxide hydrolase inhibitors from Alisma orientale and their potential mechanism with soluble epoxide hydrolase.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.187
Abstract: Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and… read more here.
Keywords: alisma orientale; soluble epoxide; hydrolase inhibitors; epoxide hydrolase ... See more keywords
A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation
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DOI: 10.1016/j.redox.2021.102107
Abstract: Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrophiles adduct within the catalytic domain, inhibiting… read more here.
Keywords: soluble epoxide; epoxide hydrolase; seh; redox ... See more keywords