The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4938-0
Abstract: RationaleAfter stimulation with nitric oxide, soluble guanylate cyclase (sGC) produces cyclic guanosine monophosphate (cGMP), which stimulates an important signalling pathway for long-term potentiation (LTP). By upregulating cGMP, LTP could be stimulated and thereby enhancing memory… read more here.
Keywords: soluble guanylate; guanylate cyclase; biperiden; performance ... See more keywords
Targeting heme-oxidized soluble guanylate cyclase to promote osteoblast function.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.12.004
Abstract: The enzyme soluble guanylate cyclase (sGC) plays an essential part in the nitric oxide (NO) signaling pathway by binding to the prosthetic heme group; thereby catalyzing the synthesis of cyclic guanosine monophosphate (cGMP)-dependent protein kinases.… read more here.
Keywords: osteoblast function; heme oxidized; soluble guanylate; guanylate cyclase ... See more keywords
Stimulation of nitric oxide‐sensitive soluble guanylate cyclase in monocrotaline‐induced pulmonary hypertensive rats
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.04.045
Abstract: Aims: In this study, we examined whether a disruption in the balance between nitric oxide (NO)‐sensitive and ‐insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO‐enhancing drugs can… read more here.
Keywords: nitric oxide; soluble guanylate; oxide sensitive; guanylate cyclase ... See more keywords
Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.08.020
Abstract: Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in platelets. Red blood cells (RBCs) are known to produce NO under… read more here.
Keywords: soluble guanylate; guanylate cyclase; signaling pathway; sgc ... See more keywords
Role of the Coiled-Coil Domain in Allosteric Activity Regulation in Soluble Guanylate Cyclase.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00052
Abstract: Soluble guanylate cyclase (sGC) is the primary nitric oxide (NO) receptor in higher eukaryotes, including humans. NO-dependent signaling via sGC is associated with important physiological effects in the vascular, pulmonary, and neurological systems, and sGC… read more here.
Keywords: soluble guanylate; coiled coil; guanylate cyclase; sgc ... See more keywords
Characterization of an NO-Activated Homodimeric Soluble Guanylate Cyclase from a Choanoflagellate.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00228
Abstract: Soluble guanylate cyclases are gas-sensing enzymes in eukaryotes that catalyze the formation of cyclic GMP from GTP. While commonly studied sGCs from insects and vertebrates are heterodimers, there are additional classes of homodimeric gas-sensing sGCs… read more here.
Keywords: sgc1; sgc1 cat; characterization activated; soluble guanylate ... See more keywords
Characterization of a Carbon Monoxide-Activated Soluble Guanylate Cyclase from Chlamydomonas reinhardtii.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00190
Abstract: Signaling pathways that involve diatomic gases in photosynthetic organisms are not well understood. Exposure to nitric oxide or carbon monoxide is known to elicit certain responses in some photosynthetic organisms. For example, Chlamydomonas reinhardtii grown… read more here.
Keywords: cyg11; carbon; soluble guanylate; guanylate cyclase ... See more keywords
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02154
Abstract: Herein we describe the discovery, mode of action, and preclinical characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of cyclic guanosine monophoshphate, is a key regulator of body… read more here.
Keywords: soluble guanylate; guanylate cyclase; sgc; activator runcaciguat ... See more keywords
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02082
Abstract: Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the very broad therapeutic opportunities for sGC stimulators, new tailored molecules for distinct indications with specific pharmacokinetics,… read more here.
Keywords: sgc stimulators; guanylate cyclase; hypertension; bay 747 ... See more keywords
Vasodilatory effects of trans-3-methoxy-β-nitrostyrene, a synthetic nitroderivative, on rat thoracic aorta: involvement of soluble guanylate cyclase stimulation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001783
Abstract: Previously, we showed that vasorelaxant effects of trans-4-methoxy-β-nitrostyrene (T4MN) in rat aorta were mediated through stimulation of the soluble guanylate cyclase (sGC) pathway. The present study tested the hypothesis that bonding of the methoxy electron-donor… read more here.
Keywords: effects trans; rat; trans methoxy; methoxy nitrostyrene ... See more keywords
SAT0283 SOLUBLE GUANYLATE CYCLASE REDUCED THE GASTROINTESTINAL FIBROSIS IN BLEOMYCIN-INDUCED MOUSE MODEL OF SYSTEMIC SCLEROSIS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.2768
Abstract: Systemic scleroderma (SSc) is a chronic autoimmune-mediated connective tissue disorder. Although the etiology of the disease remains undermined, SSc is characterized by fibrosis and proliferative vascular lesions of the skin and internal organs. SSc involves… read more here.
Keywords: blm treated; soluble guanylate; fibrosis; treated mice ... See more keywords