Soluble Guanylyl Cyclase Alpha1 Subunit: A New Marker for Estrogenicity of Endocrine Disruptor Compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4591
Abstract: Endocrine disruptor compounds (EDCs) comprise naturally occurring and synthetic substances widely spread in the environment that adversely affect human and wildlife. Because of the increasing number of EDCs, screening methods and ideal biomarkers to determine… read more here.
Keywords: soluble guanylyl; disruptor compounds; guanylyl cyclase; endocrine disruptor ... See more keywords
Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1548-7
Abstract: Earlier studies on isolated arteries demonstrated that the para-quinone thymoquinone, like acute hypoxia, induces augmentation of contractions, depending on biased activity of soluble guanylyl cyclase (sGC), generating inosine-3′,5′-cyclic monophosphate (cyclic IMP) rather than guanosine-3′,5′-cyclic monophosphate… read more here.
Keywords: augmented contractions; soluble guanylyl; isolated arteries; activity soluble ... See more keywords
Thermal shift assay: Strengths and weaknesses of the method to investigate the ligand-induced thermostabilization of soluble guanylyl cyclase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113065
Abstract: Thermal shift assay is a fluorescence dye based biochemical method to determine the melting point of a protein. It can be used to investigate the ligand-induced stabilization of proteins and helps to increase the likelihood… read more here.
Keywords: shift; shift assay; ligand induced; soluble guanylyl ... See more keywords
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16087
Abstract: BACKGROUND AND PURPOSE Alcohol abuse has been associated with erectile dysfunction (ED) but the molecular mechanisms implicated are unknown. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED. EXPERIMENTAL APPROACH… read more here.
Keywords: soluble guanylyl; guanylyl cyclase; erectile dysfunction; sgc ... See more keywords
Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040906
Abstract: Soluble guanylyl cyclase (GC1) and oxido-reductase thioredoxin (Trx1) form a complex that mediates two NO signaling pathways as a function of the redox state of cells. Under physiological conditions, reduced Trx1 (rTrx1) supports the canonical… read more here.
Keywords: soluble guanylyl; guanylyl cyclase; activity; gc1 ... See more keywords
Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111412
Abstract: Endothelial dysfunction (ED) comes with age, even without overt vessel damage such as that which occurs in atherosclerosis and diabetic vasculopathy. We hypothesized that aging would affect the downstream signalling of the endothelial nitric oxide… read more here.
Keywords: age; vasorelaxation; mesenteric arteries; soluble guanylyl ... See more keywords
Soluble Guanylyl Cyclase Activators—Promising Therapeutic Option in the Pharmacotherapy of Heart Failure and Pulmonary Hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020861
Abstract: Endogenous nitric oxide (NO)-dependent vascular relaxation plays a leading role in the homeostasis of the cardiovascular, pulmonary, and vascular systems and organs, such as the kidneys, brain, and liver. The mechanism of the intracellular action… read more here.
Keywords: soluble guanylyl; pulmonary hypertension; heart failure; guanylyl cyclase ... See more keywords