Rewiring T-cell responses to soluble factors with chimeric antigen receptors
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemical biology"
DOI: 10.1038/nchembio.2565
Abstract: Chimeric antigen receptor (CAR)-expressing T cells targeting surface-bound tumor antigens have yielded promising clinical outcomes, with two CD19 CAR-T cell therapies recently receiving FDA approval for the treatment of B-cell malignancies. The adoption of CARs… read more here.
Keywords: soluble ligands; cell responses; responses soluble; cell ... See more keywords
Soluble ligands as drug targets
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/s41573-020-0078-4
Abstract: Historically, the main classes of drug targets have been receptors, enzymes, ion channels and transporters. However, owing largely to the rise of antibody-based therapies in the past two decades, soluble protein ligands such as inflammatory… read more here.
Keywords: drug; drug targets; soluble ligands; ligands drug ... See more keywords