Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200086
Abstract: Amyloid fibril formation plays a central role in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer and Parkinson diseases. Transient prefibrillar oligomers forming during the aggregation process, exhibiting a small size and a… read more here.
Keywords: oligomers main; fibrils act; reservoir soluble; soluble oligomers ... See more keywords
Enzymatic post-hydrolysis of water-soluble cellulose oligomers released by chemical hydrolysis for cellulosic butanol production
Sign Up to like & getrecommendations! Published in 2019 at "Cellulose"
DOI: 10.1007/s10570-019-02397-x
Abstract: A process consisting of regeneration of crystalline cellulose, dilute-phosphoric acid hydrolysis of regenerated cellulose to soluble oligomers, and enzymatic post-hydrolysis of soluble oligomers in the absence of disturbing solid particles was evaluated as a process… read more here.
Keywords: post hydrolysis; cellulose; soluble oligomers; hydrolysis ... See more keywords
Structural differences of the soluble oligomers and insoluble polymers from acid-catalyzed conversion of sugars with varied structures.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.04.012
Abstract: In this paper, acid-catalyzed conversion of nine sugars (xylose, glucose, fructose, galactose, sucrose, maltose, lactose, raffinose, and β-cyclodextrin) with different sizes, steric structures and functionalities were investigated and impacts of the varied sugars on structures… read more here.
Keywords: insoluble polymers; oligomers insoluble; catalyzed conversion; carbon materials ... See more keywords
Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.06.029
Abstract: Protein aggregates are one of the several risk factors for undesired immunogenicity of biopharmaceuticals. However, it remains unclear which features determine whether aggregates will trigger an unwanted immune response. The aim of this study was… read more here.
Keywords: size particles; submicron size; soluble oligomers; micron size ... See more keywords
Nanoelectrochemistry reveals how soluble Aβ42 oligomers alter vesicular storage and release of glutamate.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219994120
Abstract: Glutamate (Glu) is the major excitatory transmitter in the nervous system. Impairment of its vesicular release by β-amyloid (Aβ) oligomers is thought to participate in pathological processes leading to Alzheimer's disease. However, it remains unclear… read more here.
Keywords: nanoelectrochemistry reveals; reveals soluble; glu; release ... See more keywords
Synaptic Disruption by Soluble Oligomers in Patients with Alzheimer’s and Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071743
Abstract: Neurodegenerative diseases are the result of progressive dysfunction of the neuronal activity and subsequent neuronal death. Currently, the most prevalent neurodegenerative diseases are by far Alzheimer’s (AD) and Parkinson’s (PD) disease, affecting millions of people… read more here.
Keywords: alzheimer parkinson; disease; synaptic disruption; parkinson disease ... See more keywords