Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis
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DOI: 10.1038/s41598-022-08227-8
Abstract: Roundabout 4 (Robo4) is a transmembrane receptor that expresses specifically in endothelial cells. Soluble Robo4 was reported in the human plasma and mouse serum and is inhibitory towards FGF- and VEGF-induced angiogenesis. It remains unknown… read more here.
Keywords: soluble robo4; angiogenesis; robo4 constitutively; induced angiogenesis ... See more keywords