Soluble Uric Acid Activates the NLRP3 Inflammasome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep39884
Abstract: Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in… read more here.
Keywords: nlrp3 inflammasome; uric acid; activates nlrp3; soluble uric ... See more keywords
Factors modulating the inflammatory response in acute gouty arthritis
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DOI: 10.1097/bor.0000000000000366
Abstract: Purpose of review Gout is a common debilitating form of arthritis and despite our extensive knowledge on the pathogenesis its prevalence is still rising quickly. In the current review, we provide a concise overview of… read more here.
Keywords: gouty; inflammatory response; soluble uric; gout ... See more keywords
Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2020.44948.10482
Abstract: Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal… read more here.
Keywords: uric acid; intestinal epithelial; epithelial cells; soluble uric ... See more keywords
Functional identification of soluble uric acid as an endogenous inhibitor of CD38
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DOI: 10.7554/elife.96962
Abstract: Excessive elevation or reduction of soluble uric acid (sUA) levels has been linked to some of pathological states, raising another subject that sUA at physiological levels may be essential for the maintenance of health. Yet,… read more here.
Keywords: identification soluble; cd38; soluble uric; functional identification ... See more keywords