Formulation and Evaluation of Lipid/Soluplus-Stabilized Nanocrystals of Paclitaxel and Bosutinib for a Synergistic Effect in Non-Small Cell Lung Cancer Therapy.
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DOI: 10.1021/acs.molpharmaceut.4c01334
Abstract: Tyrosine kinase inhibitors have been employed for the treatment of lung cancer, owing to their role in regulating irregulated pathways or mutated genes. Bosutinib, a nonreceptor tyrosine kinase, has been recently investigated for lung cancer… read more here.
Keywords: soluplus stabilized; cancer; lung cancer; stabilized nanocrystals ... See more keywords
Soluplus Stabilized Amorphous Dispersions for Enhanced Oral Absorption of Felodipine.
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DOI: 10.2174/0115672018363757241216061705
Abstract: BACKGROUND Overcoming the poor aqueous solubility of small-molecule drugs is a major challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium calcium channel blocker, is a poorly water-soluble drug. OBJECTIVES The study aimed to… read more here.
Keywords: soluplus stabilized; fldp ssas; drug; amorphous dispersions ... See more keywords