Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition☆
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2016.06.004
Abstract: &NA; Drug pharmacokinetics is influenced by the function of metabolising enzymes and influx/efflux transporters. Genetic variability of these genes is known to impact on clinical therapies. Solute Carrier Transporters (SLCs) are the primary influx transporters… read more here.
Keywords: recent advance; carrier transporters; solute carrier; drug ... See more keywords
Solute carrier proteins and c-Myc: a strong connection in cancer progression.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.02.007
Abstract: Solute carrier proteins (SLCs), the most understudied and second largest group of membrane proteins, maintain cellular metabolic homeostasis via the export and import of various solute, ions, metabolites, and even drugs. Given the importance of… read more here.
Keywords: connection; solute carrier; cancer; progression ... See more keywords
Organic solute carrier 22 (SLC22) family: Potential for interactions with food, herbal/dietary supplements, endogenous compounds, and drugs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of food and drug analysis"
DOI: 10.1016/j.jfda.2018.03.002
Abstract: Many drugs, hormones, components of herbal medicines, environmental pesticides and toxins are Solute Carrier family 22 (SLC22) substrates. The last twenty years has seen great progress in determining SLC22 tissue expression profiles, membrane localization, energetics,… read more here.
Keywords: solute carrier; family; drug; slc22 family ... See more keywords
Membrane‐enriched solute carrier family 2 member 1 (SLC2A1/GLUT1) in psoriatic keratinocytes confers sensitivity to 2‐deoxy‐D‐glucose (2‐DG) treatment
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.13850
Abstract: Psoriasis is a common chronic disease with accelerated epidermal cell growth. Solute carrier family 2 member 1 (SLC2A1), also named GLUT1, transports glucose and its analogues into cells. With elevated membrane‐bound GLUT1, psoriatic keratinocytes uptake… read more here.
Keywords: family member; member slc2a1; solute carrier; glut1 psoriatic ... See more keywords
Solute carrier family 11 member 1 genetic polymorphisms rs17235409 and rs3731865 associate with susceptibility to extremity post‐traumatic osteomyelitis in a Chinese Han population
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12620
Abstract: Genetic variations in the solute carrier family 11 member 1 (SLC11A1) gene have been implicated in developing inflammatory disorders. However, it is still unclear whether such polymorphisms contribute to the pathogenesis of post‐traumatic osteomyelitis (PTOM).… read more here.
Keywords: solute carrier; rs17235409 rs3731865; carrier family; ptom ... See more keywords
Transcriptional Regulation of Solute Carrier Drug Transporters
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DOI: 10.1124/dmd.121.000704
Abstract: Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly including organic anion-transporting polypeptides, organic anion transporters, organic cation… read more here.
Keywords: transcriptional regulation; drug; drug transporters; solute carrier ... See more keywords
Comprehensive Substrate Characterization of 22 Antituberculosis Drugs for Multiple Solute Carrier (SLC) Uptake Transporters In Vitro
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00512-18
Abstract: The substrate potentials of antituberculosis drugs on solute carrier (SLC) transporters are not well characterized to date, despite a well-established understanding of their drug dispositions and pharmacokinetics. In this study, we investigated comprehensively the substrate… read more here.
Keywords: solute carrier; drug; antituberculosis drugs; carrier slc ... See more keywords
Maternal Primary Carnitine Deficiency and a Novel Solute Carrier Family 22 Member 5 (SLC22A5) Mutation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Investigative Medicine High Impact Case Reports"
DOI: 10.1177/23247096211019543
Abstract: Primary carnitine deficiency (PCD) is a rare autosomal recessive disorder caused by loss of function mutations in the solute carrier family 22 member 5 (SLC22A5) gene that encodes a high-affinity sodium-ion–dependent organic cation transporter protein… read more here.
Keywords: carnitine deficiency; solute carrier; carrier family; primary carnitine ... See more keywords
Clinical significance of high expression of a specific solute carrier transporter in HCC.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.303
Abstract: 303Background: Hepatocellular carcinoma (HCC) is the third cause of cancer-related death. GNS561 (Genoscience Pharma, France) is a small molecule inducing apoptosis by lysosome inhibition and caspase activation. GNS561 has high hepatotropism and anti-tumorigenic capacity on… read more here.
Keywords: carrier transporter; solute carrier; specific solute;
Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family.
Sign Up to like & getrecommendations! Published in 2023 at "European thyroid journal"
DOI: 10.1530/etj-23-0023
Abstract: OBJECTIVE Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified. Members of the solute carrier (SLC)… read more here.
Keywords: thyroid hormone; solute carrier; family; sulfated iodothyronines ... See more keywords
Solute carrier transporters: potential targets for digestive system neoplasms
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DOI: 10.2147/cmar.s152951
Abstract: Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues of digestive… read more here.
Keywords: system; digestive system; slc proteins; solute carrier ... See more keywords