Targeting solute carriers to modulate receptor-ligand interactions.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2022.02.004
Abstract: Solute carrier transporters (SLCs) limit receptor activation via uptake of extracellular ligands. Novel concepts are emerging that describe the modulation of intracellular and plasma membrane receptors by ligand influx and efflux via SLCs, respectively. Here,… read more here.
Keywords: carriers modulate; solute; modulate receptor; receptor ... See more keywords
Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infection in the salivary glands
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06317-6
Abstract: Malaria is caused by mosquito-borne Plasmodium spp. parasites that must infect and survive within mosquito salivary glands (SGs) prior to host transmission. Recent advances in transcriptomics and the complete genome sequencing of mosquito vectors have… read more here.
Keywords: solute carriers; infection; anopheles stephensi; berghei ... See more keywords
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression
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DOI: 10.1098/rsob.170142
Abstract: Solute carriers (SLCs) are vital as they are responsible for a major part of the molecular transport over lipid bilayers. At present, there are 430 identified SLCs, of which 28 are called atypical SLCs of… read more here.
Keywords: slcs; solute carriers; facilitator superfamily; major facilitator ... See more keywords
Role of SLC4 and SLC26 solute carriers during oxidative stress.
Sign Up to like & getrecommendations! Published in 2022 at "Acta physiologica"
DOI: 10.1111/apha.13796
Abstract: Bicarbonate is one of the major anions in mammalian tissues and fluids, is utilized by various exchangers to transport other ions and organic substrates across cell membranes and plays a critical role in cell and… read more here.
Keywords: stress; oxidative stress; role slc4; solute carriers ... See more keywords
A substrate‐based ontology for human solute carriers
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Systems Biology"
DOI: 10.15252/msb.20209652
Abstract: Solute carriers (SLCs) are the largest family of transmembrane transporters in the human genome with more than 400 members. Despite the fact that SLCs mediate critical biological functions and several are important pharmacological targets, a… read more here.
Keywords: ontology; substrate based; solute carriers; based ontology ... See more keywords
The Roles of Solute Carriers in Auditory Function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.823049
Abstract: Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs… read more here.
Keywords: solute carriers; carriers auditory; auditory function; roles solute ... See more keywords
Optimizing the Substrate Uptake Rate of Solute Carriers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.817886
Abstract: The diversity in solute carriers arose from evolutionary pressure. Here, we surmised that the adaptive search for optimizing the rate of substrate translocation was also shaped by the ambient extracellular and intracellular concentrations of substrate… read more here.
Keywords: solute carriers; uptake rate; rate; substrate uptake ... See more keywords
Allosteric modulators of solute carrier function: a theoretical framework
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1166450
Abstract: Large-scale drug screening is currently the basis for the identification of new chemical entities. This is a rather laborious approach, because a large number of compounds must be tested to cover the chemical space in… read more here.
Keywords: solute carrier; solute carriers; carrier function; allosteric modulators ... See more keywords