Syntheses, solution behavior, and computational bond length analyses of trifluoromethyl and perfluoroethyl cuprate salts
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2020.109518
Abstract: Abstract Heteroleptic cuprate salts of the form [X-Cu-Y][(SIMes)2Cu] (SIMes = 1,3-dimesitylimidazolin-2-ylidene, X and Y = permutations of Cl, CF3, C2F5) were generated by equilibrating mixtures of [(SIMes)Cu-X] and [(SIMes)Cu-Y] in CD2Cl2 solvent. The solubility features… read more here.
Keywords: computational bond; syntheses solution; behavior computational; solution behavior ... See more keywords
In-solution behavior and protective potential of asparagine synthetase A from Trypanosoma cruzi.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2019.03.002
Abstract: l-Asparagine synthetase (AS) acts in asparagine formation and can be classified into two families: AS-A or AS-B. AS-A is mainly found in prokaryotes and can synthetize asparagine from ammonia. Distinct from other eukaryotes, Trypanosoma cruzi… read more here.
Keywords: solution behavior; trypanosoma cruzi; asparagine synthetase;
Solution behavior and magnetic properties of a novel nonanuclear copper(II) cluster
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj04230f
Abstract: A novel nonanuclear copper(II) nanocluster (Cu9) was constructed from a well-designed multidentate pyrazole–alcohol ligand and using various small anions. The Cu9 skeleton was found to consist of two similar Cu5 cluster units sharing one central… read more here.
Keywords: solution behavior; nonanuclear copper; behavior magnetic; novel nonanuclear ... See more keywords
Solution behavior and encapsulation properties of fatty acid–elastin-like polypeptide conjugates
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra06603c
Abstract: Developing new biomaterials is an active research area owing to their applications in regenerative medicine, tissue engineering and drug delivery. Elastin-like polypeptides (ELPs) are good candidates for these applications because they are biosourced, biocompatible and… read more here.
Keywords: solution behavior; fatty acid; behavior encapsulation; elastin like ... See more keywords
Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2021.1978132
Abstract: ABSTRACT Biotherapeutics are an important class of molecules for the treatment of a wide range of diseases. They include low molecular weight peptides, highly engineered protein scaffolds and monoclonal antibodies. During their discovery and development,… read more here.
Keywords: monoclonal antibodies; solution behavior; antibody; solution ... See more keywords
A single molecular descriptor to predict solution behavior of therapeutic antibodies
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb0372
Abstract: Colloidal interactions in dilute solution singularly enable selection of well-behaved antibodies during drug discovery. Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of developable mAb drug candidates with optimal manufacturability, stability, and delivery… read more here.
Keywords: descriptor; single molecular; solution behavior; well behaved ... See more keywords