Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19F NMR Spectroscopy
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DOI: 10.1021/acsomega.2c03316
Abstract: With renewed interest in atropisomerism of drug molecules, efficient methods to experimentally determine torsion rotational energy barriers are needed. Here, we describe use of the chiral phosphoric acid solvating agent (+)-TiPSY to resolve the signals… read more here.
Keywords: spectroscopy; solvating agent; 19f nmr; kinetics mrtx1719 ... See more keywords
Enantiodiscrimination Using a Chiral Crown Ether as a Chiral Solvating Agent Using NMR Spectroscopy
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DOI: 10.1177/1934578x19849191
Abstract: For enantiomer separation of a variety of chiral compounds, a number of chiral selectors have been developed and applied. Among these chiral selectors are chiral crown ethers, a class of synthetic polyether molecules that bind… read more here.
Keywords: solvating agent; crown ether; spectroscopy; chiral solvating ... See more keywords