Investigation of Solvent Hydron Exchange in the Reaction Catalyzed by the Antibiotic Resistance Protein Cfr.
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DOI: 10.1021/acs.biochem.8b00347
Abstract: Cfr is a radical S-adenosylmethionine (RS) methylase that appends methyl groups to C8 and C2 of adenosine 2503 in 23S rRNA. Methylation of C8 confers resistance to several classes of antibiotics that bind in or… read more here.
Keywords: protein; methylation; solvent hydron; reaction ... See more keywords