Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12701
Abstract: Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences in… read more here.
Keywords: status epilepticus; sex based; sex; soman ... See more keywords
Neuroprotective Effects of Galantamine on Nerve Agent-Induced Neuroglial and Biochemical Changes
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9815-9
Abstract: Neuroprotection from nerve agent such as soman-induced neural damage is a major challenge for existing drugs. Nerve agent exposure can cause many neural effects in survivors arising mainly due to acetylcholinesterase (AChE) inhibition or death… read more here.
Keywords: agent; exposure; soman; nerve agent ... See more keywords
Prophylactic potential of memantine against soman poisoning in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.01.012
Abstract: BACKGROUND Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and… read more here.
Keywords: effect memantine; soman poisoning; soman; poisoning rats ... See more keywords
Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.11.006
Abstract: Medical countermeasures for acute poisoning by organophosphorus nerve agents are generally assessed over 24h following poisoning and a single administration of treatment. At 24h, the antinicotinic bispyridinium compound MB327 (1,10-(propane-1,3-diyl)bis(4-tert-butylpyridinium)) dimethanesulfonate is as effective as… read more here.
Keywords: protection; treatment; end point; soman ... See more keywords
Anticonvulsant effectiveness of scopolamine against soman-induced seizures in African green monkeys.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2021.1916171
Abstract: Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that… read more here.
Keywords: scopolamine; induced seizures; african green; soman induced ... See more keywords
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice.
Sign Up to like & getrecommendations! Published in 2023 at "Toxicology mechanisms and methods"
DOI: 10.1080/15376516.2023.2202730
Abstract: Organophosphorus nerve agents pose a global threat to both military personnel and civilian population, because of their high acute toxicity and insufficient medical countermeasures. Commonly used drugs could ameliorate the intoxication and overall medical outcomes.… read more here.
Keywords: combination; toxicity; combination acetylcholinesterase; soman ... See more keywords
Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24050827
Abstract: Here, we introduced a novel thiourea-based rhodamine compound as a chromo-fluorogenic indicator of nerve agent Soman and its simulant diethyl chlorophosphate (DCP). The synthesized probe N-(rhodamine B)-lactam-2-(4-cyanophenyl) thiourea (RB-CT), which has a rhodamine core linked… read more here.
Keywords: based rhodamine; thiourea based; soman simulant; soman ... See more keywords