Combination of antiseizure medications phenobarbital, ketamine and midazolam reduces soman-induced epileptogenesis and brain pathology in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia open"
DOI: 10.1002/epi4.12552
Abstract: OBJECTIVE Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that may contribute to pharmacoresistance… read more here.
Keywords: ketamine; midazolam; pathology; soman induced ... See more keywords
Anticonvulsant effectiveness of scopolamine against soman-induced seizures in African green monkeys.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2021.1916171
Abstract: Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that… read more here.
Keywords: scopolamine; induced seizures; african green; soman induced ... See more keywords