Interaction analysis between germline susceptibility loci and somatic alterations in lung cancer
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DOI: 10.1002/ijc.31351
Abstract: Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. However, the germline–somatic interaction in lung cancer remains largely unknown. We investigated whether lung cancer driver genes (CDGs) were more likely to… read more here.
Keywords: susceptibility; analysis; lung cancer; cancer ... See more keywords
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
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DOI: 10.1038/s41591-020-0839-y
Abstract: PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced… read more here.
Keywords: renal cell; response; infiltration; blockade ... See more keywords
Whole-exome sequencing of tumour-only samples reveals the association between somatic alterations and clinical features in pancreatic cancer
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DOI: 10.1093/annonc/mdz431.012
Abstract: Abstract Background Perturbations in key driver genes or recurrently somatic mutated genes, as well as altered signaling pathways underlying pancreatic cancer have been largely discovered with the help of massive parallel sequencing. However, to date,… read more here.
Keywords: clinical features; whole exome; pancreatic cancer; cancer ... See more keywords
MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations
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DOI: 10.1093/gigascience/giab036
Abstract: Abstract Background Multi-region sequencing (MRS) has been widely used to analyze intra-tumor heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational data from MRS is still challenging, necessitating complicated integration of a plethora of… read more here.
Keywords: meskit; cancer; cancer evolution; somatic alterations ... See more keywords
Short somatic alterations at the site of copy number variation in breast cancer
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DOI: 10.1111/cas.14630
Abstract: Copy number variation (CNV) is a polymorphism in the human genome involving DNA fragments larger than 1 kb. Copy number variation sites provide hotspots of somatic alterations in cancers. Herein, we examined somatic alterations at… read more here.
Keywords: copy number; number variation; breast; number ... See more keywords
Lack of Significant Differences in Somatic Alterations between MGUS, SMM and Symptomatic Multiple Myeloma: A Result from Comprehensive Genomic Profiling Study
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DOI: 10.1182/blood-2019-128570
Abstract: Somatic alterations including single nucleotide variants (SNVs), copy number alterations (CNAs) and structural variants (SVs) are an important component and the hallmark of Multiple Myeloma (MM) with certain alterations having clinical implications. Recently, the chronological… read more here.
Keywords: iqr; consultancy; mgus smm; smm ... See more keywords
Distinct somatic alterations in right- versus left-sided colorectal cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3592
Abstract: 3592Background: Right-sided (RCC) and left-sided colon cancers (LCC) have different clinical/biological characteristics. Comprehensive genomic analysis (Whole exome/genome, Copy number, RNA, MicroR... read more here.
Keywords: left sided; right versus; versus left; alterations right ... See more keywords
Somatic Alterations Impact AR Transcriptional Activity and Efficacy of AR-Targeting Therapies in Prostate Cancer
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DOI: 10.3390/cancers13163947
Abstract: Simple Summary For patients whose prostate cancer spreads beyond the confines of the prostate, treatment options continue to increase. However, we are missing the information that is needed to choose for each patient the best… read more here.
Keywords: androgen; treatment; prostate cancer; cancer ... See more keywords