MND1 enables homologous recombination in somatic cells primarily outside the context of replication.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13448
Abstract: Faithful and timely repair of DNA double-strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co-factor MND1 facilitates the repair of DSBs in somatic cells. We… read more here.
Keywords: recombination; mnd1 enables; replication; mnd1 ... See more keywords
Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26784
Abstract: Direct reprogramming represents an easy technique to generate induced hepatocytes (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here,… read more here.
Keywords: hepatocyte like; like cells; repopulate decellularized; direct reprogramming ... See more keywords
Dendritic cells generated from induced pluripotent stem cells and by direct reprogramming of somatic cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149550
Abstract: Novel and exciting avenues allow generating dendritic cells (DC) by reprogramming of somatic cells. DC are obtained from induced pluripotent stem cells (iPS cells), referred to as ipDC, and by direct reprogramming of cells toward… read more here.
Keywords: pluripotent stem; direct reprogramming; somatic cells; reprogramming somatic ... See more keywords
PiRNAs, PiRNA‐Like, and PIWI Proteins in Somatic Cells: From Genetic Regulation to Disease Mechanisms
Sign Up to like & getrecommendations! Published in 2025 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.70012
Abstract: PIWI‐interacting RNAs (piRNAs) are small non‐coding RNA molecules that were originally described as responsible for binding to PIWI proteins to silence transposons in the germline genome. Here we discuss their controversial influence in regulating gene… read more here.
Keywords: human somatic; non coding; somatic cells; pirna like ... See more keywords
Reprogramming of Aged Cells into Pluripotent Stem Cells by Nuclear Transfer.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2018_118
Abstract: Stem cells have the potential to differentiate into specialized cell types under specific conditions in vivo or in vitro, which are used to cure many diseases related to aging. Somatic cell nuclear transfer (SCNT) can… read more here.
Keywords: nuclear transfer; aged cells; stem; stem cells ... See more keywords
Use of commercial somatic cell counters to quantify somatic cells in non-lactating bovine mammary gland secretions.
Sign Up to like & getrecommendations! Published in 2019 at "Preventive veterinary medicine"
DOI: 10.1016/j.prevetmed.2019.104775
Abstract: Measurement of the somatic cell count (SCC) in milk is commonly used to detect mastitis in lactating dairy cows. Many techniques and tools have been developed and adapted to quantify milk SCC, but few tools… read more here.
Keywords: non lactating; somatic cell; mammary secretions; cells non ... See more keywords
Germ cell regeneration-mediated, enhanced mutagenesis in the ascidian Ciona intestinalis reveals flexible germ cell formation from different somatic cells.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.01.022
Abstract: The ascidian Ciona intestinalis has a high regeneration capacity that enables the regeneration of artificially removed primordial germ cells (PGCs) from somatic cells. We utilized PGC regeneration to establish efficient methods of germ line mutagenesis… read more here.
Keywords: ciona; mutagenesis; regeneration; germ cell ... See more keywords
Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn1017-1427a
Abstract: Nat. Neurosci. 19, 1583–1591 (2016); published online 12 September 2016; corrected after print 13 July 2017 In the version of this article initially published, NIH grant T32 CA009370 to F.H.G. was missing from the Acknowledgments.… read more here.
Keywords: deleted somatic; regions deleted; genomic regions; corrigendum associated ... See more keywords
A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04132-9
Abstract: Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3). Most of those ERVs, including IAPs, remain silent if Setdb1 is… read more here.
Keywords: setdb1; silencing somatic; erv silencing; somatic role ... See more keywords
AAV vector-mediated in vivo reprogramming into pluripotency
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05059-x
Abstract: In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4,… read more here.
Keywords: vivo reprogramming; vector; vector mediated; aav vector ... See more keywords
Mitochondrial DNA mosaicism in normal human somatic cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Genetics"
DOI: 10.1038/s41588-024-01838-z
Abstract: Somatic cells accumulate genomic alterations with age; however, our understanding of mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes of 2,096 clones derived from three cell types across 31 donors, identifying 6,451… read more here.
Keywords: human somatic; dna mosaicism; mosaicism; somatic cells ... See more keywords