Genome‐wide analysis of colorectal cancer based on gene‐based somatic copy number alterations during neoplastic progression within the same tumor
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5117
Abstract: The objective of this study was to elucidate the association between neoplastic progression and somatic copy number alterations (SCNAs) occurring within the same colorectal cancer (CRC) tumor. read more here.
Keywords: number alterations; somatic copy; neoplastic progression; colorectal cancer ... See more keywords
Refinement of computational identification of somatic copy number alterations using DNA methylation microarrays illustrated in cancers of unknown primary
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac161
Abstract: Abstract High-throughput genomic technologies are increasingly used in personalized cancer medicine. However, computational tools to maximize the use of scarce tissues combining distinct molecular layers are needed. Here we present a refined strategy, based on… read more here.
Keywords: methylation; number alterations; somatic copy; dna methylation ... See more keywords
Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275453.121
Abstract: Genomic-scale somatic copy number alterations in healthy humans are difficult to investigate because of low occurrence rates and the structural variations' stochastic natures. Using a Tn5-transposase-assisted single-cell whole-genome sequencing method, we sequenced over 20,000 single… read more here.
Keywords: somatic copy; copy number; number alterations; single cell ... See more keywords
Comprehensive analysis of intratumoural heterogeneity of somatic copy number alterations in diffuse glioma reveals clonality‐dependent prognostic patterns
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12831
Abstract: Intratumoural heterogeneity (ITH) has been implicated in tumour growth and progression as well as therapy resistance. However, the extent of ITH of somatic copy number alterations (ITH‐SCNAs) as a result of tumour evolution and its… read more here.
Keywords: intratumoural heterogeneity; number alterations; somatic copy; diffuse glioma ... See more keywords
Somatic Copy-Number Alterations Occur in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-159
Abstract: In colorectal cancer, somatic copy-number alterations (SCNA) were common even in nonmalignant cells. read more here.
Keywords: somatic copy; copy number; alterations occur; number alterations ... See more keywords
Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0176045
Abstract: Gastric cancer, a leading worldwide cause of cancer mortality, shows high geographic and ethnic variation in incidence rates, which are highest in East Asia. The anatomic locations and clinical behavior also differ by geography, leading… read more here.
Keywords: somatic copy; copy number; western patients; gastric adenocarcinomas ... See more keywords
CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11101411
Abstract: Simple Summary The ability to establish accurate correlations between the number of copies of genes and the expression levels of their encoded transcripts remains a challenge despite the extensive progress made in the understanding of… read more here.
Keywords: somatic copy; cancer; copy number; expression ... See more keywords